TY - JOUR
T1 - Immunological aspects of cancer chemotherapy
AU - Zitvogel, Laurence
AU - Apetoh, Lionel
AU - Ghiringhelli, François
AU - Kroemer, Guido
N1 - Funding Information:
The authors are supported by grants from the Ligue Nationale contre le Cancer (L.Z., G.K. and L.A.), the European Union (ALLOSTEM, DC-THERA; L.Z.), Cancéropôle Île-de-France, Institut National du Cancer and Agence Nationale pour la Recherche (G.K.). F.G. is supported by a Poste d’acceuil INSERM.
PY - 2008/1/1
Y1 - 2008/1/1
N2 - Accumulating evidence indicates that the innate and adaptive immune systems make a crucial contribution to the antitumour effects of conventional chemotherapy-based and radiotherapy-based cancer treatments. Moreover, the molecular and cellular bases of the immunogenicity of cell death that is induced by cytotoxic agents are being progressively unravelled, challenging the guidelines that currently govern the development of anticancer drugs. Here, we review the immunological aspects of conventional cancer treatments and propose that future successes in the fight against cancer will rely on the development and clinical application of combined chemo- and immunotherapies.
AB - Accumulating evidence indicates that the innate and adaptive immune systems make a crucial contribution to the antitumour effects of conventional chemotherapy-based and radiotherapy-based cancer treatments. Moreover, the molecular and cellular bases of the immunogenicity of cell death that is induced by cytotoxic agents are being progressively unravelled, challenging the guidelines that currently govern the development of anticancer drugs. Here, we review the immunological aspects of conventional cancer treatments and propose that future successes in the fight against cancer will rely on the development and clinical application of combined chemo- and immunotherapies.
UR - http://www.scopus.com/inward/record.url?scp=37549032137&partnerID=8YFLogxK
U2 - 10.1038/nri2216
DO - 10.1038/nri2216
M3 - Review article
C2 - 18097448
AN - SCOPUS:37549032137
SN - 1474-1733
VL - 8
SP - 59
EP - 73
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 1
ER -