Immunological aspects of cancer chemotherapy

Laurence Zitvogel; Lionel Apetoh; François Ghiringhelli; Guido Kroemer

doi:10.1038/nri2216

Immunological aspects of cancer chemotherapy

Laurence Zitvogel, Lionel Apetoh, François Ghiringhelli, Guido Kroemer

Résultats de recherche: Contribution à un journal › Article 'review' › Revue par des pairs

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Résumé

Accumulating evidence indicates that the innate and adaptive immune systems make a crucial contribution to the antitumour effects of conventional chemotherapy-based and radiotherapy-based cancer treatments. Moreover, the molecular and cellular bases of the immunogenicity of cell death that is induced by cytotoxic agents are being progressively unravelled, challenging the guidelines that currently govern the development of anticancer drugs. Here, we review the immunological aspects of conventional cancer treatments and propose that future successes in the fight against cancer will rely on the development and clinical application of combined chemo- and immunotherapies.

langue originale	Anglais
Pages (de - à)	59-73
Nombre de pages	15
journal	Nature Reviews Immunology
Volume	8
Numéro de publication	1
Les DOIs	https://doi.org/10.1038/nri2216
état	Publié - 1 janv. 2008

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10.1038/nri2216

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title = "Immunological aspects of cancer chemotherapy",

abstract = "Accumulating evidence indicates that the innate and adaptive immune systems make a crucial contribution to the antitumour effects of conventional chemotherapy-based and radiotherapy-based cancer treatments. Moreover, the molecular and cellular bases of the immunogenicity of cell death that is induced by cytotoxic agents are being progressively unravelled, challenging the guidelines that currently govern the development of anticancer drugs. Here, we review the immunological aspects of conventional cancer treatments and propose that future successes in the fight against cancer will rely on the development and clinical application of combined chemo- and immunotherapies.",

author = "Laurence Zitvogel and Lionel Apetoh and Fran{\c c}ois Ghiringhelli and Guido Kroemer",

note = "Funding Information: The authors are supported by grants from the Ligue Nationale contre le Cancer (L.Z., G.K. and L.A.), the European Union (ALLOSTEM, DC-THERA; L.Z.), Canc{\'e}rop{\^o}le {\^I}le-de-France, Institut National du Cancer and Agence Nationale pour la Recherche (G.K.). F.G. is supported by a Poste d{\textquoteright}acceuil INSERM.",

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AU - Apetoh, Lionel

AU - Ghiringhelli, François

AU - Kroemer, Guido

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