TY - JOUR
T1 - Immunometabolic Rewiring
T2 - A Tale of Macronutrients and Macrophages
AU - Anagnostopoulos, Gerasimos
AU - Blériot, Camille
AU - Venteclef, Nicolas
AU - Ginhoux, Florent
N1 - Publisher Copyright:
© 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG.
PY - 2024/1/1
Y1 - 2024/1/1
N2 - Myeloid cells, including monocytes, macrophages, dendritic cells, and polymorphonuclear cells are key components of homeostasis maintenance and immune response. Among the myeloid lineage, macrophages stand out as highly versatile cells that safeguard tissue functions but also sense and respond to potentially harmful microenvironmental cues. Numerous studies have demonstrated that the nutritional status and macronutrient availability affect macrophage identity and function. However, the exact mechanistic links between macronutrient intake and cellular metabolic shifts are only beginning to be understood. In this chapter, we explore how dietary "macros"-carbohydrates, fats, and amino acids-impact the immunomodulatory activity of macrophages in healthy and inflamed tissues.
AB - Myeloid cells, including monocytes, macrophages, dendritic cells, and polymorphonuclear cells are key components of homeostasis maintenance and immune response. Among the myeloid lineage, macrophages stand out as highly versatile cells that safeguard tissue functions but also sense and respond to potentially harmful microenvironmental cues. Numerous studies have demonstrated that the nutritional status and macronutrient availability affect macrophage identity and function. However, the exact mechanistic links between macronutrient intake and cellular metabolic shifts are only beginning to be understood. In this chapter, we explore how dietary "macros"-carbohydrates, fats, and amino acids-impact the immunomodulatory activity of macrophages in healthy and inflamed tissues.
KW - Immunometabolism
KW - Macronutrient intake
KW - Resident tissue macrophages (RTMs)
UR - http://www.scopus.com/inward/record.url?scp=85206501552&partnerID=8YFLogxK
U2 - 10.1007/978-3-031-65944-7_3
DO - 10.1007/978-3-031-65944-7_3
M3 - Review article
C2 - 39406902
AN - SCOPUS:85206501552
SN - 0080-1844
VL - 74
SP - 89
EP - 118
JO - Results and problems in cell differentiation
JF - Results and problems in cell differentiation
ER -