Immunometabolic Rewiring: A Tale of Macronutrients and Macrophages

Gerasimos Anagnostopoulos, Camille Blériot, Nicolas Venteclef, Florent Ginhoux

    Résultats de recherche: Contribution à un journalArticle 'review'Revue par des pairs

    Résumé

    Myeloid cells, including monocytes, macrophages, dendritic cells, and polymorphonuclear cells are key components of homeostasis maintenance and immune response. Among the myeloid lineage, macrophages stand out as highly versatile cells that safeguard tissue functions but also sense and respond to potentially harmful microenvironmental cues. Numerous studies have demonstrated that the nutritional status and macronutrient availability affect macrophage identity and function. However, the exact mechanistic links between macronutrient intake and cellular metabolic shifts are only beginning to be understood. In this chapter, we explore how dietary "macros"-carbohydrates, fats, and amino acids-impact the immunomodulatory activity of macrophages in healthy and inflamed tissues.

    langue originaleAnglais
    Pages (de - à)89-118
    Nombre de pages30
    journalResults and problems in cell differentiation
    Volume74
    Les DOIs
    étatPublié - 1 janv. 2024

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