Immunosuppression by Mutated Calreticulin Released from Malignant Cells

Peng Liu; Liwei Zhao; Friedemann Loos; Caroline Marty; Wei Xie; Isabelle Martins; Sylvie Lachkar; Bo Qu; Emmanuelle Waeckel-Énée; Isabelle Plo; William Vainchenker; Franck Perez; David Rodriguez; Carlos López-Otin; Peter van Endert; Laurence Zitvogel; Oliver Kepp; Guido Kroemer

doi:10.1016/j.molcel.2019.11.004

Immunosuppression by Mutated Calreticulin Released from Malignant Cells

Peng Liu, Liwei Zhao, Friedemann Loos, Caroline Marty, Wei Xie, Isabelle Martins, Sylvie Lachkar, Bo Qu, Emmanuelle Waeckel-Énée, Isabelle Plo, William Vainchenker, Franck Perez, David Rodriguez, Carlos López-Otin, Peter van Endert, Laurence Zitvogel, Oliver Kepp, Guido Kroemer

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

78 Citations (Scopus)

Résumé

Mutations affecting exon 9 of the CALR gene can be found in many forms of cancer and lead to the calreticulin (CALR) protein that is released. Liu et al. have shown that extracellular CALR inhibits the phagocytosis by dendritic cells, exerts immunosuppressive effects, and suppresses the effect of anticancer immunotherapy.

langue originale	Anglais
Pages (de - à)	748-760.e9
journal	Molecular Cell
Volume	77
Numéro de publication	4
Les DOIs	https://doi.org/10.1016/j.molcel.2019.11.004
état	Publié - 20 févr. 2020

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10.1016/j.molcel.2019.11.004

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Liu, P., Zhao, L., Loos, F., Marty, C., Xie, W., Martins, I., Lachkar, S., Qu, B., Waeckel-Énée, E., Plo, I., Vainchenker, W., Perez, F., Rodriguez, D., López-Otin, C., van Endert, P., Zitvogel, L., Kepp, O., & Kroemer, G. (2020). Immunosuppression by Mutated Calreticulin Released from Malignant Cells. Molecular Cell, 77(4), 748-760.e9. https://doi.org/10.1016/j.molcel.2019.11.004

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title = "Immunosuppression by Mutated Calreticulin Released from Malignant Cells",

abstract = "Mutations affecting exon 9 of the CALR gene can be found in many forms of cancer and lead to the calreticulin (CALR) protein that is released. Liu et al. have shown that extracellular CALR inhibits the phagocytosis by dendritic cells, exerts immunosuppressive effects, and suppresses the effect of anticancer immunotherapy.",

keywords = "CD47 blockade, ICD, PD-1, RUSH, calreticulin, immunogenic cell death, immunosuppression, phagocytosis, retention using selective hooks",

author = "Peng Liu and Liwei Zhao and Friedemann Loos and Caroline Marty and Wei Xie and Isabelle Martins and Sylvie Lachkar and Bo Qu and Emmanuelle Waeckel-{\'E}n{\'e}e and Isabelle Plo and William Vainchenker and Franck Perez and David Rodriguez and Carlos L{\'o}pez-Otin and {van Endert}, Peter and Laurence Zitvogel and Oliver Kepp and Guido Kroemer",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2020",

month = feb,

day = "20",

doi = "10.1016/j.molcel.2019.11.004",

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Liu, P, Zhao, L, Loos, F, Marty, C, Xie, W, Martins, I, Lachkar, S, Qu, B, Waeckel-Énée, E, Plo, I, Vainchenker, W, Perez, F, Rodriguez, D, López-Otin, C, van Endert, P, Zitvogel, L, Kepp, O & Kroemer, G 2020, 'Immunosuppression by Mutated Calreticulin Released from Malignant Cells', Molecular Cell, VOL. 77, Numéro 4, p. 748-760.e9. https://doi.org/10.1016/j.molcel.2019.11.004

TY - JOUR

T1 - Immunosuppression by Mutated Calreticulin Released from Malignant Cells

AU - Liu, Peng

AU - Zhao, Liwei

AU - Loos, Friedemann

AU - Marty, Caroline

AU - Xie, Wei

AU - Martins, Isabelle

AU - Lachkar, Sylvie

AU - Qu, Bo

AU - Waeckel-Énée, Emmanuelle

AU - Plo, Isabelle

AU - Vainchenker, William

AU - Perez, Franck

AU - Rodriguez, David

AU - López-Otin, Carlos

AU - van Endert, Peter

AU - Zitvogel, Laurence

AU - Kepp, Oliver

AU - Kroemer, Guido

PY - 2020/2/20

Y1 - 2020/2/20

N2 - Mutations affecting exon 9 of the CALR gene can be found in many forms of cancer and lead to the calreticulin (CALR) protein that is released. Liu et al. have shown that extracellular CALR inhibits the phagocytosis by dendritic cells, exerts immunosuppressive effects, and suppresses the effect of anticancer immunotherapy.

AB - Mutations affecting exon 9 of the CALR gene can be found in many forms of cancer and lead to the calreticulin (CALR) protein that is released. Liu et al. have shown that extracellular CALR inhibits the phagocytosis by dendritic cells, exerts immunosuppressive effects, and suppresses the effect of anticancer immunotherapy.

KW - CD47 blockade

KW - ICD

KW - PD-1

KW - RUSH

KW - calreticulin

KW - immunogenic cell death

KW - immunosuppression

KW - phagocytosis

KW - retention using selective hooks

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U2 - 10.1016/j.molcel.2019.11.004

DO - 10.1016/j.molcel.2019.11.004

M3 - Article

C2 - 31785928

AN - SCOPUS:85077149674

SN - 1097-2765

VL - 77

SP - 748-760.e9

JO - Molecular Cell

JF - Molecular Cell

IS - 4

ER -