Immunosurveillance in clinical cancer management

Guido Kroemer, Timothy A. Chan, Alexander M.M. Eggermont, Lorenzo Galluzzi

    Résultats de recherche: Contribution à un journalArticle 'review'Revue par des pairs

    34 Citations (Scopus)

    Résumé

    The progression of cancer involves a critical step in which malignant cells escape from control by the immune system. Antineoplastic agents are particularly efficient when they succeed in restoring such control (immunosurveillance) or at least establish an equilibrium state that slows down disease progression. This is true not only for immunotherapies, such as immune checkpoint inhibitors (ICIs), but also for conventional chemotherapy, targeted anticancer agents, and radiation therapy. Thus, therapeutics that stress and kill cancer cells while provoking a tumor-targeting immune response, referred to as immunogenic cell death, are particularly useful in combination with ICIs. Modern oncology regimens are increasingly using such combinations, which are referred to as chemoimmunotherapy, as well as combinations of multiple ICIs. However, the latter are generally associated with severe side effects compared with single-agent ICIs. Of note, the success of these combinatorial strategies against locally advanced or metastatic cancers is now spurring successful attempts to move them past the postoperative (adjuvant) setting to the preoperative (neoadjuvant) setting, even for patients with operable cancers. Here, the authors critically discuss the importance of immunosurveillance in modern clinical cancer management.

    langue originaleAnglais
    Pages (de - à)187-202
    Nombre de pages16
    journalCA Cancer Journal for Clinicians
    Volume74
    Numéro de publication2
    Les DOIs
    étatPublié - 1 mars 2024

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