Immunosurveillance in esophageal carcinoma: The decisive impact of regulatory T cells

Erika Vacchelli; Michaela Semeraro; Julien Adam; Peggy Dartigues; Laurence Zitvogel; Guido Kroemer

doi:10.1080/2162402X.2015.1064581

Immunosurveillance in esophageal carcinoma: The decisive impact of regulatory T cells

Erika Vacchelli, Michaela Semeraro, Julien Adam, Peggy Dartigues, Laurence Zitvogel, Guido Kroemer

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

12 Citations (Scopus)

Résumé

Neoadjuvant radiochemotherapy of esophageal carcinomas causes a variable degree of depletion of tumor-infiltrating FOXP3⁺ regulatory T cells (Tregs). The frequency of local Tregs in the operative specimens negatively correlates with the pathological response and overall patient survival. These results underscore the importance of immunosurveillance in determining the fate of patients with esophageal cancers treated with radiochemotherapy.

langue originale	Anglais
journal	OncoImmunology
Volume	5
Numéro de publication	2
Les DOIs	https://doi.org/10.1080/2162402X.2015.1064581
état	Publié - 1 févr. 2016

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10.1080/2162402X.2015.1064581

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abstract = "Neoadjuvant radiochemotherapy of esophageal carcinomas causes a variable degree of depletion of tumor-infiltrating FOXP3+ regulatory T cells (Tregs). The frequency of local Tregs in the operative specimens negatively correlates with the pathological response and overall patient survival. These results underscore the importance of immunosurveillance in determining the fate of patients with esophageal cancers treated with radiochemotherapy.",

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