Immunosurveillance of Malignant Cells with Complex Karyotypes

Alejandro López-Soto; Segundo Gonzalez; Carlos López-Larrea; Guido Kroemer

doi:10.1016/j.tcb.2017.09.001

Immunosurveillance of Malignant Cells with Complex Karyotypes

Alejandro López-Soto, Segundo Gonzalez, Carlos López-Larrea, Guido Kroemer

Résultats de recherche: Contribution à un journal › Brève enquête › Revue par des pairs

11 Citations (Scopus)

Résumé

A wide array of cell-intrinsic surveillance mechanisms maintains the homeostasis of dividing cells and the integrity of the genome. Accumulating evidence also supports a role for cell-extrinsic mechanisms. Among them, the immune system, together with cell-autonomous checkpoint processes, eliminates cells that harbor unbalanced karyotypes generated by mitotic defects.

langue originale	Anglais
Pages (de - à)	880-884
Nombre de pages	5
journal	Trends in Cell Biology
Volume	27
Numéro de publication	12
Les DOIs	https://doi.org/10.1016/j.tcb.2017.09.001
état	Publié - 1 déc. 2017

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10.1016/j.tcb.2017.09.001

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abstract = "A wide array of cell-intrinsic surveillance mechanisms maintains the homeostasis of dividing cells and the integrity of the genome. Accumulating evidence also supports a role for cell-extrinsic mechanisms. Among them, the immune system, together with cell-autonomous checkpoint processes, eliminates cells that harbor unbalanced karyotypes generated by mitotic defects.",

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