Immunotherapies in non-muscle invasive bladder cancer: immunotherapies and NMIBC

Yohann Loriot; Morgan Rouprêt

doi:10.1016/S0007-4551(20)30278-2

Immunotherapies in non-muscle invasive bladder cancer: immunotherapies and NMIBC

Titre traduit de la contribution: Immunothérapie des tumeurs de la vessie n'infiltrant pas le muscle: immunothérapies et TVNIM

Yohann Loriot, Morgan Rouprêt

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

2 Citations (Scopus)

Résumé

Local and systemic immunotherapies are used for the management of bladder cancer in daily practice. BCG has been administered for almost 40 years in patients with non-muscle invasive bladder cancer (NMIBC). Despite its efficacy, disease progression is observed in nearly 30% of patients. Given the antitumor activity of immune checkpoint inhibitors in metastatic setting, these therapies are currently investigated in NMIBC. Pembrolizumab is now approved by the Food and Drug Administration (FDA) for the treatment of patients with BCG-unresponsive, high-risk, NMIBC with carcinoma in situ with or without papillary tumors who are ineligible for or have not elected to undergo cystectomy. Several phase 3 trials are ongoing to investigate the efficacy of PD(L)1 inhibitors combined with BCG such as ALBAN study in France.

Titre traduit de la contribution	Immunothérapie des tumeurs de la vessie n'infiltrant pas le muscle: immunothérapies et TVNIM
langue originale	Anglais
Pages (de - à)	S49-S55
journal	Bulletin du Cancer
Volume	107
Numéro de publication	5
Les DOIs	https://doi.org/10.1016/S0007-4551(20)30278-2
état	Publié - 1 juin 2020

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10.1016/S0007-4551(20)30278-2

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title = "Immunotherapies in non-muscle invasive bladder cancer: immunotherapies and NMIBC",

abstract = "Local and systemic immunotherapies are used for the management of bladder cancer in daily practice. BCG has been administered for almost 40 years in patients with non-muscle invasive bladder cancer (NMIBC). Despite its efficacy, disease progression is observed in nearly 30% of patients. Given the antitumor activity of immune checkpoint inhibitors in metastatic setting, these therapies are currently investigated in NMIBC. Pembrolizumab is now approved by the Food and Drug Administration (FDA) for the treatment of patients with BCG-unresponsive, high-risk, NMIBC with carcinoma in situ with or without papillary tumors who are ineligible for or have not elected to undergo cystectomy. Several phase 3 trials are ongoing to investigate the efficacy of PD(L)1 inhibitors combined with BCG such as ALBAN study in France.",

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