Immunotherapy with interleukin-2 (IL2) and lymphokine-activated natural killer cells: Improvement of clinical responses in metastatic renal cell carcinoma patients previously treated with IL2

B. Escudier, F. Farace, E. Angevin, F. Charpentier, G. Nitenberg, F. Triebel, T. Hercend

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    Résumé

    Treatment with interleukin-2 (IL2) induces clinical responses in 15-30% of metastatic renal cell carcinoma (MRCC) patients, with mainly partial responses. In order to improve clinical response, we decided to treat partial response patients from a previous IL2 treatment with a second course of IL2 associated with lymphokine-activated natural killer (LANAK) cells. 10 patients who underwent PR after an IL2 protocol (24 × 106 U/m2/day, 2 days a week for 5 weeks, either alone or with interferon-γ) subsequently received a combination of high-dose IL2 (16-20 × 106 U/m2/day, 2 days a week) and LANAK cell infusions. Four complete responses were obtained, and 2 additional patients whose tumour mass was further reduced achieved complete response following surgery. These results support the view that initial responses obtained with primary IL2 courses can be improved by complementary treatments. The potential role of cellular immunotherapy and, more particularly, of LANAK cells as an effective procedure to further reduce tumour burden in patients responsive to IL2 will have to be assessed in randomised studies.

    langue originaleAnglais
    Pages (de - à)1078-1083
    Nombre de pages6
    journalEuropean Journal of Cancer
    Volume30
    Numéro de publication8
    Les DOIs
    étatPublié - 1 janv. 1994

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