Impact of exogenous galectin-9 on human T cells contribution of the T cell receptor complex to antigen-independent activation but not to apoptosis induction

Claire Lhuillier; Clément Barjon; Toshiro Niki; Aurore Gelin; Françoise Praz; Olivier Morales; Sylvie Souquere; Mitsuomi Hirashima; Ming Wei; Olivier Dellis; Pierre Busson

doi:10.1074/jbc.M115.661272

Impact of exogenous galectin-9 on human T cells contribution of the T cell receptor complex to antigen-independent activation but not to apoptosis induction

Claire Lhuillier, Clément Barjon, Toshiro Niki, Aurore Gelin, Françoise Praz, Olivier Morales, Sylvie Souquere, Mitsuomi Hirashima, Ming Wei, Olivier Dellis, Pierre Busson

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

51 Citations (Scopus)

Résumé

Background: Signals triggered by galectin-9 in human T cells are poorly understood. Results: Impairment of Lck or T cell receptor-CD3 complex inhibits calcium mobilization and cytokine production but not apoptosis induced by galectin-9. Conclusion: Galectin-9 triggers two independent pathways in T cells, with one mimicking the antigen-specific activation. Significance: We discovered a novel mechanism involved in galectin-9 immunomodulatory effects.

langue originale	Anglais
Pages (de - à)	16797-16811
Nombre de pages	15
journal	Journal of Biological Chemistry
Volume	290
Numéro de publication	27
Les DOIs	https://doi.org/10.1074/jbc.M115.661272
état	Publié - 3 juil. 2015

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10.1074/jbc.M115.661272

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Lhuillier, C., Barjon, C., Niki, T., Gelin, A., Praz, F., Morales, O., Souquere, S., Hirashima, M., Wei, M., Dellis, O., & Busson, P. (2015). Impact of exogenous galectin-9 on human T cells contribution of the T cell receptor complex to antigen-independent activation but not to apoptosis induction. Journal of Biological Chemistry, 290(27), 16797-16811. https://doi.org/10.1074/jbc.M115.661272

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title = "Impact of exogenous galectin-9 on human T cells contribution of the T cell receptor complex to antigen-independent activation but not to apoptosis induction",

abstract = "Background: Signals triggered by galectin-9 in human T cells are poorly understood. Results: Impairment of Lck or T cell receptor-CD3 complex inhibits calcium mobilization and cytokine production but not apoptosis induced by galectin-9. Conclusion: Galectin-9 triggers two independent pathways in T cells, with one mimicking the antigen-specific activation. Significance: We discovered a novel mechanism involved in galectin-9 immunomodulatory effects.",

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Lhuillier, C, Barjon, C, Niki, T, Gelin, A, Praz, F, Morales, O, Souquere, S, Hirashima, M, Wei, M, Dellis, O & Busson, P 2015, 'Impact of exogenous galectin-9 on human T cells contribution of the T cell receptor complex to antigen-independent activation but not to apoptosis induction', Journal of Biological Chemistry, VOL. 290, Numéro 27, p. 16797-16811. https://doi.org/10.1074/jbc.M115.661272

Impact of exogenous galectin-9 on human T cells contribution of the T cell receptor complex to antigen-independent activation but not to apoptosis induction. / Lhuillier, Claire; Barjon, Clément; Niki, Toshiro et al.
Dans: Journal of Biological Chemistry, Vol 290, Numéro 27, 03.07.2015, p. 16797-16811.

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

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AU - Lhuillier, Claire

AU - Barjon, Clément

AU - Niki, Toshiro

AU - Gelin, Aurore

AU - Praz, Françoise

AU - Morales, Olivier

AU - Souquere, Sylvie

AU - Hirashima, Mitsuomi

AU - Wei, Ming

AU - Dellis, Olivier

AU - Busson, Pierre

PY - 2015/7/3

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