TY - JOUR
T1 - Impact of prophylactic central neck dissection on oncologic outcomes of papillary thyroid carcinoma
T2 - a review
AU - Mamelle, Elisabeth
AU - Borget, Isabelle
AU - Leboulleux, Sophie
AU - Mirghani, Haïtham
AU - Suárez, Carlos
AU - Pellitteri, Phillip K.
AU - Shaha, Ashok R.
AU - Hamoir, Marc
AU - Robbins, K. Thomas
AU - Khafif, Avi
AU - Rodrigo, Juan P.
AU - Silver, Carl E.
AU - Rinaldo, Alessandra
AU - Ferlito, Alfio
AU - Hartl, Dana M.
N1 - Publisher Copyright:
© 2014, Springer-Verlag Berlin Heidelberg.
PY - 2015/7/26
Y1 - 2015/7/26
N2 - Prophylactic neck dissection (PND) for papillary thyroid carcinoma (PTC) is controversial. Our aim was to assess current levels of evidence (LE) according to the Oxford Centre for Evidence-based Medicine (http://www.cebm.net/?O=1025) regarding the oncologic benefits of PND. Data were analyzed via MEDLINE keywords: PTC, differentiated thyroid carcinoma, PND, central lymph node metastases, central compartment, recurrence-free survival. There was conflicting evidence regarding the rate of reoperation for recurrence, with some studies showing a lower rate after PND with increased recurrence-free survival and a higher rate of undetectable pre- and post-ablation thyroglobulin levels (LE 4), whereas other studies did not show a difference (LE 4). Only one study (LE 4) showed improved disease-specific survival with PND. PND may improve recurrence-free survival, although this is supported by only a low LE. Current recommendations can only be based on low-level evidence.
AB - Prophylactic neck dissection (PND) for papillary thyroid carcinoma (PTC) is controversial. Our aim was to assess current levels of evidence (LE) according to the Oxford Centre for Evidence-based Medicine (http://www.cebm.net/?O=1025) regarding the oncologic benefits of PND. Data were analyzed via MEDLINE keywords: PTC, differentiated thyroid carcinoma, PND, central lymph node metastases, central compartment, recurrence-free survival. There was conflicting evidence regarding the rate of reoperation for recurrence, with some studies showing a lower rate after PND with increased recurrence-free survival and a higher rate of undetectable pre- and post-ablation thyroglobulin levels (LE 4), whereas other studies did not show a difference (LE 4). Only one study (LE 4) showed improved disease-specific survival with PND. PND may improve recurrence-free survival, although this is supported by only a low LE. Current recommendations can only be based on low-level evidence.
KW - Lymph node metastasis
KW - Papillary thyroid carcinoma
KW - Prophylactic neck dissection
KW - Radioactive iodine
KW - Recurrence-free survival
UR - http://www.scopus.com/inward/record.url?scp=84929707195&partnerID=8YFLogxK
U2 - 10.1007/s00405-014-3104-5
DO - 10.1007/s00405-014-3104-5
M3 - Review article
C2 - 25022716
AN - SCOPUS:84929707195
SN - 0937-4477
VL - 272
SP - 1577
EP - 1586
JO - European Archives of Oto-Rhino-Laryngology
JF - European Archives of Oto-Rhino-Laryngology
IS - 7
M1 - 3104
ER -