Impact of radiation therapy on healthy tissues

Cyrus Chargari, Elie Rassy, Carole Helissey, Samir Achkar, Sabine Francois, Eric Deutsch

    Résultats de recherche: Le chapitre dans un livre, un rapport, une anthologie ou une collection!!ChapterRevue par des pairs

    5 Citations (Scopus)

    Résumé

    Radiation therapy has a fundamental role in the management of cancers. However, despite a constant improvement in radiotherapy techniques, the issue of radiation-induced side effects remains clinically relevant. Mechanisms of acute toxicity and late fibrosis are therefore important topics for translational research to improve the quality of life of patients treated with ionizing radiations. Tissue changes observed after radiotherapy are consequences of complex pathophysiology, involving macrophage activation, cytokine cascade, fibrotic changes, vascularization disorders, hypoxia, tissue destruction and subsequent chronic wound healing. Moreover, numerous data show the impact of these changes in the irradiated stroma on the oncogenic process, with interplays between tumor radiation response and pathways involved in the fibrotic process. The mechanisms of radiation-induced normal tissue inflammation are reviewed, with a focus on the impact of the inflammatory process on the onset of treatment-related toxicities and the oncogenic process. Possible targets for pharmacomodulation are also discussed.

    langue originaleAnglais
    titreIonizing Radiation and the Immune Response - Part A
    rédacteurs en chefCéline Mirjolet, Lorenzo Galluzzi
    EditeurElsevier Inc.
    Pages69-98
    Nombre de pages30
    ISBN (imprimé)9780323955232
    Les DOIs
    étatPublié - 1 janv. 2023

    Série de publications

    NomInternational Review of Cell and Molecular Biology
    Volume376
    ISSN (imprimé)1937-6448

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