Résumé
This review explores the role of c-MYC in Chronic Lymphocytic Leukemia (CLL) and its impact on genetic instability and disease progression. As a key oncogene, c-MYC encodes a transcription factor involved in regulating cell cycle, growth, and apoptosis. We previously described CLL cases enriched with unmutated IGHV genes, MYC overexpression and with active rearrangement of the IGH immunoglobulin heavy chain (IGH) locus. The MYC overexpression seems to promote increased DNA damage, including double-strand breaks (DSBs), chromosomal translocations linked to repair errors during DNA repair. Highlighting c-MYC’s dual role, this review try to show how MYC overexpression it not only driving cell proliferation but also contributes to genomic instability.
langue originale | Anglais |
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Numéro d'article | 3749 |
journal | Cancers |
Volume | 16 |
Numéro de publication | 22 |
Les DOIs | |
état | Publié - 1 nov. 2024 |