Increased c-MYC Expression Associated with Active IGH Locus Rearrangement: An Emerging Role for c-MYC in Chronic Lymphocytic Leukemia

Kenza Guiyedi, Milène Parquet, Said Aoufouchi, Jasmine Chauzeix, David Rizzo, Israa Al Jamal, Jean Feuillard, Nathalie Gachard, Sophie Peron

    Résultats de recherche: Contribution à un journalArticle 'review'Revue par des pairs

    Résumé

    This review explores the role of c-MYC in Chronic Lymphocytic Leukemia (CLL) and its impact on genetic instability and disease progression. As a key oncogene, c-MYC encodes a transcription factor involved in regulating cell cycle, growth, and apoptosis. We previously described CLL cases enriched with unmutated IGHV genes, MYC overexpression and with active rearrangement of the IGH immunoglobulin heavy chain (IGH) locus. The MYC overexpression seems to promote increased DNA damage, including double-strand breaks (DSBs), chromosomal translocations linked to repair errors during DNA repair. Highlighting c-MYC’s dual role, this review try to show how MYC overexpression it not only driving cell proliferation but also contributes to genomic instability.

    langue originaleAnglais
    Numéro d'article3749
    journalCancers
    Volume16
    Numéro de publication22
    Les DOIs
    étatPublié - 1 nov. 2024

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