Induction chemotherapy followed by radiotherapy for N3 head and neck squamous cell carcinoma

Chengrun Du; Pierre Blanchard; Caroline Even; Angela Boros; Philippe Gorphe; Ingrid Breuskin; Neus Baste-Rotllan; France Nguyen; Amandine Ruffier; François Bidault; Camélia Billard; François Janot; Haitham Mirghani; Stephane Temam; Yungan Tao

doi:10.1002/hed.26021

Induction chemotherapy followed by radiotherapy for N3 head and neck squamous cell carcinoma

Chengrun Du, Pierre Blanchard, Caroline Even, Angela Boros, Philippe Gorphe, Ingrid Breuskin, Neus Baste-Rotllan, France Nguyen, Amandine Ruffier, François Bidault, Camélia Billard, François Janot, Haitham Mirghani, Stephane Temam, Yungan Tao

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4 Citations (Scopus)

Résumé

Background: The treatment outcomes for N3 HNSCC treated with induction chemotherapy (ICT) followed by definitive radiation were reported to clarify the role of ICT and potential prognostic factors. Methods: A retrospective study was conducted on 120 patients with N3 (≥6 cm) HNSCC, who were treated with ICT as initial treatment. Survival outcomes and potential prognostic factors were reported. Results: The response rate to ICT was 68.3%. There was a statistically significant difference between responders and non-responders in terms of 5-year OS (35.1% vs 13.3%, P <.001) and PFS (29.4% vs 7.4%, P <.001). Good response to ICT (P <.001) and upfront neck dissection (UFND) before radiotherapy (P =.016) were factors predicting for better OS. However, UFND before radiotherapy was not associated with improved outcomes among responders. Conclusions: This study suggests that ICT could be one treatment option for N3 HNSCC. Among responders to ICT, UFND before radiotherapy could be avoided.

langue originale	Anglais
Pages (de - à)	426-433
Nombre de pages	8
journal	Head and Neck
Volume	42
Numéro de publication	3
Les DOIs	https://doi.org/10.1002/hed.26021
état	Publié - 1 mars 2020

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10.1002/hed.26021

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title = "Induction chemotherapy followed by radiotherapy for N3 head and neck squamous cell carcinoma",

abstract = "Background: The treatment outcomes for N3 HNSCC treated with induction chemotherapy (ICT) followed by definitive radiation were reported to clarify the role of ICT and potential prognostic factors. Methods: A retrospective study was conducted on 120 patients with N3 (≥6 cm) HNSCC, who were treated with ICT as initial treatment. Survival outcomes and potential prognostic factors were reported. Results: The response rate to ICT was 68.3%. There was a statistically significant difference between responders and non-responders in terms of 5-year OS (35.1% vs 13.3%, P <.001) and PFS (29.4% vs 7.4%, P <.001). Good response to ICT (P <.001) and upfront neck dissection (UFND) before radiotherapy (P =.016) were factors predicting for better OS. However, UFND before radiotherapy was not associated with improved outcomes among responders. Conclusions: This study suggests that ICT could be one treatment option for N3 HNSCC. Among responders to ICT, UFND before radiotherapy could be avoided.",

keywords = "N3, head and neck cancers, induction chemotherapy, upfront neck dissection",

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year = "2020",

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doi = "10.1002/hed.26021",

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TY - JOUR

T1 - Induction chemotherapy followed by radiotherapy for N3 head and neck squamous cell carcinoma

AU - Du, Chengrun

AU - Blanchard, Pierre

AU - Even, Caroline

AU - Boros, Angela

AU - Gorphe, Philippe

AU - Breuskin, Ingrid

AU - Baste-Rotllan, Neus

AU - Nguyen, France

AU - Ruffier, Amandine

AU - Bidault, François

AU - Billard, Camélia

AU - Janot, François

AU - Mirghani, Haitham

AU - Temam, Stephane

AU - Tao, Yungan

PY - 2020/3/1

Y1 - 2020/3/1

N2 - Background: The treatment outcomes for N3 HNSCC treated with induction chemotherapy (ICT) followed by definitive radiation were reported to clarify the role of ICT and potential prognostic factors. Methods: A retrospective study was conducted on 120 patients with N3 (≥6 cm) HNSCC, who were treated with ICT as initial treatment. Survival outcomes and potential prognostic factors were reported. Results: The response rate to ICT was 68.3%. There was a statistically significant difference between responders and non-responders in terms of 5-year OS (35.1% vs 13.3%, P <.001) and PFS (29.4% vs 7.4%, P <.001). Good response to ICT (P <.001) and upfront neck dissection (UFND) before radiotherapy (P =.016) were factors predicting for better OS. However, UFND before radiotherapy was not associated with improved outcomes among responders. Conclusions: This study suggests that ICT could be one treatment option for N3 HNSCC. Among responders to ICT, UFND before radiotherapy could be avoided.

AB - Background: The treatment outcomes for N3 HNSCC treated with induction chemotherapy (ICT) followed by definitive radiation were reported to clarify the role of ICT and potential prognostic factors. Methods: A retrospective study was conducted on 120 patients with N3 (≥6 cm) HNSCC, who were treated with ICT as initial treatment. Survival outcomes and potential prognostic factors were reported. Results: The response rate to ICT was 68.3%. There was a statistically significant difference between responders and non-responders in terms of 5-year OS (35.1% vs 13.3%, P <.001) and PFS (29.4% vs 7.4%, P <.001). Good response to ICT (P <.001) and upfront neck dissection (UFND) before radiotherapy (P =.016) were factors predicting for better OS. However, UFND before radiotherapy was not associated with improved outcomes among responders. Conclusions: This study suggests that ICT could be one treatment option for N3 HNSCC. Among responders to ICT, UFND before radiotherapy could be avoided.

KW - N3

KW - head and neck cancers

KW - induction chemotherapy

KW - upfront neck dissection

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