TY - JOUR
T1 - Induction of resident memory T cells enhances the efficacy of cancer vaccine
AU - Nizard, Mevyn
AU - Roussel, Hélène
AU - Diniz, Mariana O.
AU - Karaki, Soumaya
AU - Tran, Thi
AU - Voron, Thibault
AU - Dransart, Estelle
AU - Sandoval, Federico
AU - Riquet, Marc
AU - Rance, Bastien
AU - Marcheteau, Elie
AU - Fabre, Elizabeth
AU - Mandavit, Marion
AU - Terme, Magali
AU - Blanc, Charlotte
AU - Escudie, Jean Baptiste
AU - Gibault, Laure
AU - Barthes, Françoise Le Pimpec
AU - Granier, Clemence
AU - Ferreira, Luis C.S.
AU - Badoual, Cecile
AU - Johannes, Ludger
AU - Tartour, Eric
PY - 2017/5/24
Y1 - 2017/5/24
N2 - Tissue-resident memory T cells (Trm) represent a new subset of long-lived memory T cells that remain in tissue and do not recirculate. Although they are considered as early immune effectors in infectious diseases, their role in cancer immunosurveillance remains unknown. In a preclinical model of head and neck cancer, we show that intranasal vaccination with a mucosal vector, the B subunit of Shiga toxin, induces local Trm and inhibits tumour growth. As Trm do not recirculate, we demonstrate their crucial role in the efficacy of cancer vaccine with parabiosis experiments. Blockade of TFGβ decreases the induction of Trm after mucosal vaccine immunization, resulting in the lower efficacy of cancer vaccine. In order to extrapolate this role of Trm in humans, we show that the number of Trm correlates with a better overall survival in lung cancer in multivariate analysis. The induction of Trm may represent a new surrogate biomarker for the efficacy of cancer vaccine. This study also argues for the development of vaccine strategies designed to elicit them.
AB - Tissue-resident memory T cells (Trm) represent a new subset of long-lived memory T cells that remain in tissue and do not recirculate. Although they are considered as early immune effectors in infectious diseases, their role in cancer immunosurveillance remains unknown. In a preclinical model of head and neck cancer, we show that intranasal vaccination with a mucosal vector, the B subunit of Shiga toxin, induces local Trm and inhibits tumour growth. As Trm do not recirculate, we demonstrate their crucial role in the efficacy of cancer vaccine with parabiosis experiments. Blockade of TFGβ decreases the induction of Trm after mucosal vaccine immunization, resulting in the lower efficacy of cancer vaccine. In order to extrapolate this role of Trm in humans, we show that the number of Trm correlates with a better overall survival in lung cancer in multivariate analysis. The induction of Trm may represent a new surrogate biomarker for the efficacy of cancer vaccine. This study also argues for the development of vaccine strategies designed to elicit them.
UR - http://www.scopus.com/inward/record.url?scp=85019914536&partnerID=8YFLogxK
U2 - 10.1038/ncomms15221
DO - 10.1038/ncomms15221
M3 - Article
C2 - 28537262
AN - SCOPUS:85019914536
SN - 2041-1723
VL - 8
JO - Nature Communications
JF - Nature Communications
M1 - 15221
ER -