Inflammatory and immune etiology of type 2 diabetes

Camille Blériot, Élise Dalmas, Florent Ginhoux, Nicolas Venteclef

    Résultats de recherche: Contribution à un journalArticle 'review'Revue par des pairs

    15 Citations (Scopus)

    Résumé

    Type 2 diabetes (T2D) represents a global threat affecting millions of patients worldwide. However, its causes remain incompletely dissected and we lack the tools to predict which individuals will develop T2D. Although there is a clear proven clinical association of T2D with metabolic disorders such as obesity and nonalcoholic fatty liver disease (NAFLD), the existence of a significant number of nondiabetic obese subjects suggests yet-uncovered features of such relationships. Here, we propose that a significant proportion of individuals may harbor an immune profile that renders them susceptible to developing T2D. We note the heterogeneity of circulating monocytes and tissue macrophages in organs that are key to metabolic disorders such as liver, white adipose tissue (WAT), and endocrine pancreas, as well as their contribution to T2D genesis.

    langue originaleAnglais
    Pages (de - à)101-109
    Nombre de pages9
    journalTrends in Immunology
    Volume44
    Numéro de publication2
    Les DOIs
    étatPublié - 1 févr. 2023

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