Influence of Different Measurement Methods of Arterial Input Function on Quantitative Dynamic Contrast-Enhanced MRI Parameters in Head and Neck Cancer

Wanxin Dong, Andreas Volk, Meriem Djaroum, Charly Girot, Corinne Balleyguier, Vincent Lebon, Gabriel Garcia, Samy Ammari, Stéphane Temam, Philippe Gorphe, Lecong Wei, Stéphanie Pitre-Champagnat, Nathalie Lassau, François Bidault

Résultats de recherche: Contribution à un journalArticleRevue par des pairs

2 Citations (Scopus)

Résumé

Background: Head and neck cancer (HNC) is the sixth most prevalent cancer worldwide. Dynamic contrast-enhanced MRI (DCE-MRI) helps in diagnosis and prognosis. Quantitative DCE-MRI requires an arterial input function (AIF), which affects the values of pharmacokinetic parameters (PKP). Purpose: To evaluate influence of four individual AIF measurement methods on quantitative DCE-MRI parameters values (Ktrans, ve, kep, and vp), for HNC and muscle. Study Type: Prospective. Population: A total of 34 HNC patients (23 males, 11 females, age range 24–91). Field Strength/Sequence: A 3 T; 3D SPGR gradient echo sequence with partial saturation of inflowing spins. Assessment: Four AIF methods were applied: automatic AIF (AIFa) with up to 50 voxels selected from the whole FOV, manual AIF (AIFm) with four voxels selected from the internal carotid artery, both conditions without (Mc−) or with (Mc+) motion correction. Comparison endpoints were peak AIF values, PKP values in tumor and muscle, and tumor/muscle PKP ratios. Statistical Tests: Nonparametric Friedman test for multiple comparisons. Nonparametric Wilcoxon test, without and with Benjamini Hochberg correction, for pairwise comparison of AIF peak values and PKP values for tumor, muscle and tumor/muscle ratio, P value ≤ 0.05 was considered statistically significant. Results: Peak AIF values differed significantly for all AIF methods, with mean AIFmMc+ peaks being up to 66.4% higher than those for AIFaMc+. Almost all PKP values were significantly higher for AIFa in both, tumor and muscle, up to 76% for mean Ktrans values. Motion correction effect was smaller. Considering tumor/muscle parameter ratios, most differences were not significant (0.068 ≤ Wilcoxon P value ≤ 0.8). Data Conclusion: We observed important differences in PKP values when using either AIFa or AIFm, consequently choice of a standardized AIF method is mandatory for DCE-MRI on HNC. From the study findings, AIFm and inflow compensation are recommended. The use of the tumor/muscle PKP ratio should be of interest for multicenter studies. Evidence Level: 2. Technical Efficacy: Stage 1.

langue originaleAnglais
Pages (de - à)122-132
Nombre de pages11
journalJournal of Magnetic Resonance Imaging
Volume58
Numéro de publication1
Les DOIs
étatPublié - 1 juil. 2023
Modification externeOui

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