Inheritable forms of medullary thyroid carcinoma

Anne Bachelot, Francesca Lombardo, Eric Baudin, Jean Michel Bidart, Martin Schlumberger

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    Résumé

    Medullary thyroid carcinoma (MTC) arises from parafollicular or C cells of the thyroid that produce calcitonin. It accounts for 5-10% of all thyroid cancers. Hereditary MTC represents 20-30% of all MTCs. It can be transmitted with an autosomal dominant pattern, either as a single entity, familial MTC, or it can arise as part of a multiple endocrine neoplasia (MEN) syndrome type 2A or 2B. The identification of hereditary MTC has been facilitated in recent years by the direct analysis of the ret proto-oncogene.

    langue originaleAnglais
    Pages (de - à)61-66
    Nombre de pages6
    journalBiochimie
    Volume84
    Numéro de publication1
    Les DOIs
    étatPublié - 1 janv. 2002

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