Résumé
Genome-scale metabolic reconstruction is the ultimate goal of system biologists for finding out the genotype-phenotype relationship. In this chapter, the authors aim to describe the foundational concepts, central to omics data, model formulation, history, method, and applications of metabolic network reconstruction as well as some related sources. Here, they describe omics data and high-throughput technologies for gaining these data. They present different ways for metabolic network modeling. Here, they summarize the history of genome-scale modeling as one of the most important methods for metabolic network modeling. In the chapter, they elucidate how genome-scale metabolic models could be generated and what their applications are. Finally, they review biochemical pathways and genome annotation databases.
langue originale | Anglais |
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titre | Biological Knowledge Discovery Handbook |
Sous-titre | Preprocessing, Mining and Postprocessing of Biological Data |
Editeur | wiley |
Pages | 1027-1047 |
Nombre de pages | 21 |
ISBN (Electronique) | 9781118617151 |
ISBN (imprimé) | 9781118853726 |
Les DOIs | |
état | Publié - 1 janv. 2014 |
Modification externe | Oui |