Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry.

Frank Desiere; Eric W. Deutsch; Alexey I. Nesvizhskii; Parag Mallick; Nichole L. King; Jimmy K. Eng; Alan Aderem; Rose Boyle; Erich Brunner; Samuel Donohoe; Nelson Fausto; Ernst Hafen; Lee Hood; Michael G. Katze; Kathleen A. Kennedy; Floyd Kregenow; Hookeun Lee; Biaoyang Lin; Dan Martin; Jeffrey A. Ranish; David J. Rawlings; Lawrence E. Samelson; Yuzuru Shiio; Julian D. Watts; Bernd Wollscheid; Michael E. Wright; Wei Yan; Lihong Yang; Eugene C. Yi; Hui Zhang; Ruedi Aebersold

Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry.

Frank Desiere, Eric W. Deutsch, Alexey I. Nesvizhskii, Parag Mallick, Nichole L. King, Jimmy K. Eng, Alan Aderem, Rose Boyle, Erich Brunner, Samuel Donohoe, Nelson Fausto, Ernst Hafen, Lee Hood, Michael G. Katze, Kathleen A. Kennedy, Floyd Kregenow, Hookeun Lee, Biaoyang Lin, Dan Martin, Jeffrey A. RanishDavid J. Rawlings, Lawrence E. Samelson, Yuzuru Shiio, Julian D. Watts, Bernd Wollscheid, Michael E. Wright, Wei Yan, Lihong Yang, Eugene C. Yi, Hui Zhang, Ruedi Aebersold

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

269 Citations (Scopus)

Résumé

A crucial aim upon the completion of the human genome is the verification and functional annotation of all predicted genes and their protein products. Here we describe the mapping of peptides derived from accurate interpretations of protein tandem mass spectrometry (MS) data to eukaryotic genomes and the generation of an expandable resource for integration of data from many diverse proteomics experiments. Furthermore, we demonstrate that peptide identifications obtained from high-throughput proteomics can be integrated on a large scale with the human genome. This resource could serve as an expandable repository for MS-derived proteome information.

langue originale	Anglais
Pages (de - à)	R9
journal	Genome biology
Volume	6
Numéro de publication	1
état	Publié - 1 janv. 2005
Modification externe	Oui

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Desiere, F., Deutsch, E. W., Nesvizhskii, A. I., Mallick, P., King, N. L., Eng, J. K., Aderem, A., Boyle, R., Brunner, E., Donohoe, S., Fausto, N., Hafen, E., Hood, L., Katze, M. G., Kennedy, K. A., Kregenow, F., Lee, H., Lin, B., Martin, D., ... Aebersold, R. (2005). Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry. Genome biology, 6(1), R9.

@article{db7de70a223247a9b6523772a3527bd6,

title = "Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry.",

abstract = "A crucial aim upon the completion of the human genome is the verification and functional annotation of all predicted genes and their protein products. Here we describe the mapping of peptides derived from accurate interpretations of protein tandem mass spectrometry (MS) data to eukaryotic genomes and the generation of an expandable resource for integration of data from many diverse proteomics experiments. Furthermore, we demonstrate that peptide identifications obtained from high-throughput proteomics can be integrated on a large scale with the human genome. This resource could serve as an expandable repository for MS-derived proteome information.",

author = "Frank Desiere and Deutsch, {Eric W.} and Nesvizhskii, {Alexey I.} and Parag Mallick and King, {Nichole L.} and Eng, {Jimmy K.} and Alan Aderem and Rose Boyle and Erich Brunner and Samuel Donohoe and Nelson Fausto and Ernst Hafen and Lee Hood and Katze, {Michael G.} and Kennedy, {Kathleen A.} and Floyd Kregenow and Hookeun Lee and Biaoyang Lin and Dan Martin and Ranish, {Jeffrey A.} and Rawlings, {David J.} and Samelson, {Lawrence E.} and Yuzuru Shiio and Watts, {Julian D.} and Bernd Wollscheid and Wright, {Michael E.} and Wei Yan and Lihong Yang and Yi, {Eugene C.} and Hui Zhang and Ruedi Aebersold",

year = "2005",

month = jan,

day = "1",

language = "English",

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pages = "R9",

journal = "Genome biology",

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Desiere, F, Deutsch, EW, Nesvizhskii, AI, Mallick, P, King, NL, Eng, JK, Aderem, A, Boyle, R, Brunner, E, Donohoe, S, Fausto, N, Hafen, E, Hood, L, Katze, MG, Kennedy, KA, Kregenow, F, Lee, H, Lin, B, Martin, D, Ranish, JA, Rawlings, DJ, Samelson, LE, Shiio, Y, Watts, JD, Wollscheid, B, Wright, ME, Yan, W, Yang, L, Yi, EC, Zhang, H & Aebersold, R 2005, 'Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry.', Genome biology, VOL. 6, Numéro 1, p. R9.

TY - JOUR

T1 - Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry.

AU - Desiere, Frank

AU - Deutsch, Eric W.

AU - Nesvizhskii, Alexey I.

AU - Mallick, Parag

AU - King, Nichole L.

AU - Eng, Jimmy K.

AU - Aderem, Alan

AU - Boyle, Rose

AU - Brunner, Erich

AU - Donohoe, Samuel

AU - Fausto, Nelson

AU - Hafen, Ernst

AU - Hood, Lee

AU - Katze, Michael G.

AU - Kennedy, Kathleen A.

AU - Kregenow, Floyd

AU - Lee, Hookeun

AU - Lin, Biaoyang

AU - Martin, Dan

AU - Ranish, Jeffrey A.

AU - Rawlings, David J.

AU - Samelson, Lawrence E.

AU - Shiio, Yuzuru

AU - Watts, Julian D.

AU - Wollscheid, Bernd

AU - Wright, Michael E.

AU - Yan, Wei

AU - Yang, Lihong

AU - Yi, Eugene C.

AU - Zhang, Hui

AU - Aebersold, Ruedi

PY - 2005/1/1

Y1 - 2005/1/1

N2 - A crucial aim upon the completion of the human genome is the verification and functional annotation of all predicted genes and their protein products. Here we describe the mapping of peptides derived from accurate interpretations of protein tandem mass spectrometry (MS) data to eukaryotic genomes and the generation of an expandable resource for integration of data from many diverse proteomics experiments. Furthermore, we demonstrate that peptide identifications obtained from high-throughput proteomics can be integrated on a large scale with the human genome. This resource could serve as an expandable repository for MS-derived proteome information.

AB - A crucial aim upon the completion of the human genome is the verification and functional annotation of all predicted genes and their protein products. Here we describe the mapping of peptides derived from accurate interpretations of protein tandem mass spectrometry (MS) data to eukaryotic genomes and the generation of an expandable resource for integration of data from many diverse proteomics experiments. Furthermore, we demonstrate that peptide identifications obtained from high-throughput proteomics can be integrated on a large scale with the human genome. This resource could serve as an expandable repository for MS-derived proteome information.

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