Interaction between methotrexate and ciprofloxacin

Jean Hugues Dalle; Anne Auvrignon; Gilles Vassal; Guy Leverger

doi:10.1097/00043426-200205000-00021

Interaction between methotrexate and ciprofloxacin

Jean Hugues Dalle, Anne Auvrignon, Gilles Vassal, Guy Leverger

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

49 Citations (Scopus)

Résumé

High-dose methotrexate is used in malignant hemopathies and solid tumors in children. Methotrexate serum concentrations must be monitored because of the possible toxicity of drug elimination delay. Several drugs (e.g., penicillin, probenecid) can alter the elimination of methotrexate. The authors report two cases of delayed elimination of methotrexate in patients receiving ciprofloxacin, with severe toxicity.

langue originale	Anglais
Pages (de - à)	321-322
Nombre de pages	2
journal	Journal of Pediatric Hematology/Oncology
Volume	24
Numéro de publication	4
Les DOIs	https://doi.org/10.1097/00043426-200205000-00021
état	Publié - 23 mai 2002
Modification externe	Oui

Accès au document

10.1097/00043426-200205000-00021

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abstract = "High-dose methotrexate is used in malignant hemopathies and solid tumors in children. Methotrexate serum concentrations must be monitored because of the possible toxicity of drug elimination delay. Several drugs (e.g., penicillin, probenecid) can alter the elimination of methotrexate. The authors report two cases of delayed elimination of methotrexate in patients receiving ciprofloxacin, with severe toxicity.",

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KW - Drug interaction

KW - Methotrexate

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