@article{6091a67183eb43f3baf6be8aa4e945f0,
title = "Interferon-γ is produced by another player of innate immune responses: The interferon-producing killer dendritic cell (IKDC)",
abstract = "Interferon-γ is a key cytokine in tumor immunosurveillance. The recently described interferon-producing killer dendritic cell (IKDC), can be distinguished from other innate effectors by its ability to kill a large variety of tumor cells and to produce high amounts of interferon-γ after encountering tumors in the absence of exogenous cytokines. The cytotoxic activity of IKDC was unraveled during an efficient immunotherapy combining c-kit tyrosine kinase inhibitors and interleukin-2, and is mediated through tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and interferon type IIR.",
keywords = "Dendritic cells, Imatinib mesylate, Interferon-producing killer dendritic cells, Interferon-γ, Interleukin-2, TNF-related apoptosis-inducing ligand, Tumor immunity, c-kit tyrosine kinase inhibitor",
author = "Mathieu Bonmort and Evelyn Ullrich and Gr{\'e}goire Mignot and B{\'e}n{\'e}dikt Jacobs and Nathalie Chaput and Laurence Zitvogel",
note = "Funding Information: M.B. is supported by a Poste d'accueil INSERM, E.U. received a fellowship from the German Forschungsgemeinschaft (DFG), G.M. is supported by the Association pour la Recherche contre le Cancer (ARC). This work has also been supported by EU grants (ALLOSTEM, DC THERA), ARC, and the Ligue Nationale contre le Cancer ({\'e}quipe labellis{\'e}e).",
year = "2007",
month = jun,
day = "1",
doi = "10.1016/j.biochi.2007.04.014",
language = "English",
volume = "89",
pages = "872--877",
journal = "Biochimie",
issn = "0300-9084",
number = "6-7",
}