Interleukin-2 receptor beta chain locus rearrangement in a T-cell acute lymphoblastic leukemia

R. Berger; O. A. Bernard

doi:10.1016/j.patbio.2006.04.004

Interleukin-2 receptor beta chain locus rearrangement in a T-cell acute lymphoblastic leukemia

R. Berger, O. A. Bernard

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

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Résumé

A translocation t(1;22)(p13;q13) was detected in a child with T-cell acute lymphoblastic leukemia (T-ALL). FISH studies showed that the breakpoint was located in the 5′ part of the interleukin-2 receptor beta chain (IL2RB) locus, but could only be located distal to 1p13.3 on the partner chromosome. This is the first case of the IL2RB locus rearrangement in T-ALL. The localization of the breakpoint suggests that the chromosomal translocation results in deregulation of IL2RB expression.

langue originale	Anglais
Pages (de - à)	56-58
Nombre de pages	3
journal	Pathologie Biologie
Volume	55
Numéro de publication	1
Les DOIs	https://doi.org/10.1016/j.patbio.2006.04.004
état	Publié - 1 févr. 2007
Modification externe	Oui

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10.1016/j.patbio.2006.04.004

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title = "Interleukin-2 receptor beta chain locus rearrangement in a T-cell acute lymphoblastic leukemia",

abstract = "A translocation t(1;22)(p13;q13) was detected in a child with T-cell acute lymphoblastic leukemia (T-ALL). FISH studies showed that the breakpoint was located in the 5′ part of the interleukin-2 receptor beta chain (IL2RB) locus, but could only be located distal to 1p13.3 on the partner chromosome. This is the first case of the IL2RB locus rearrangement in T-ALL. The localization of the breakpoint suggests that the chromosomal translocation results in deregulation of IL2RB expression.",

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AU - Bernard, O. A.

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AB - A translocation t(1;22)(p13;q13) was detected in a child with T-cell acute lymphoblastic leukemia (T-ALL). FISH studies showed that the breakpoint was located in the 5′ part of the interleukin-2 receptor beta chain (IL2RB) locus, but could only be located distal to 1p13.3 on the partner chromosome. This is the first case of the IL2RB locus rearrangement in T-ALL. The localization of the breakpoint suggests that the chromosomal translocation results in deregulation of IL2RB expression.

KW - IL2RB

KW - T-ALL

KW - Translocation

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