Intranodular Thyroid Metastasis of a Large Cell Neuroendocrine Carcinoma of the Endometrium

Capucine Richard; Abir Al Ghuzlan; Virginie Huchet; Vincent Cockenpot; Ségolène Hescot

doi:10.1097/RLU.0000000000005665

Intranodular Thyroid Metastasis of a Large Cell Neuroendocrine Carcinoma of the Endometrium

Capucine Richard, Abir Al Ghuzlan, Virginie Huchet, Vincent Cockenpot, Ségolène Hescot

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Résumé

A 64-year-old woman underwent initial ¹⁸F-FDG PET/CT staging for a suspicious endometrial mass, which showed high uptake in the endometrial mass and a focal uptake in a known left thyroid nodule. Histology revealed a high-grade large cell neuroendocrine carcinoma of the endometrium with FIGO (International Federation of Gynecology and Obstetrics) stage Ib. Further explorations revealed a synchronous thyroid metastasis. Patient then received adjuvant immunochemotherapy. This case showed a potential pitfall in the initial assessment of this rare and aggressive malignancy on which the therapeutic approach greatly depends.

langue originale	Anglais
Pages (de - à)	e388-e390
journal	Clinical Nuclear Medicine
Volume	50
Numéro de publication	6
Les DOIs	https://doi.org/10.1097/RLU.0000000000005665
état	Publié - 1 juin 2025

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10.1097/RLU.0000000000005665

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title = "Intranodular Thyroid Metastasis of a Large Cell Neuroendocrine Carcinoma of the Endometrium",

abstract = "A 64-year-old woman underwent initial 18F-FDG PET/CT staging for a suspicious endometrial mass, which showed high uptake in the endometrial mass and a focal uptake in a known left thyroid nodule. Histology revealed a high-grade large cell neuroendocrine carcinoma of the endometrium with FIGO (International Federation of Gynecology and Obstetrics) stage Ib. Further explorations revealed a synchronous thyroid metastasis. Patient then received adjuvant immunochemotherapy. This case showed a potential pitfall in the initial assessment of this rare and aggressive malignancy on which the therapeutic approach greatly depends.",

keywords = "F-FDG PET/CT, adjuvant therapy, endometrium, large cell neuroendocrine carci-noma, thyroid metastasis, uterus",

author = "Capucine Richard and {Al Ghuzlan}, Abir and Virginie Huchet and Vincent Cockenpot and S{\'e}gol{\`e}ne Hescot",

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AU - Richard, Capucine

AU - Al Ghuzlan, Abir

AU - Huchet, Virginie

AU - Cockenpot, Vincent

AU - Hescot, Ségolène

PY - 2025/6/1

Y1 - 2025/6/1

N2 - A 64-year-old woman underwent initial 18F-FDG PET/CT staging for a suspicious endometrial mass, which showed high uptake in the endometrial mass and a focal uptake in a known left thyroid nodule. Histology revealed a high-grade large cell neuroendocrine carcinoma of the endometrium with FIGO (International Federation of Gynecology and Obstetrics) stage Ib. Further explorations revealed a synchronous thyroid metastasis. Patient then received adjuvant immunochemotherapy. This case showed a potential pitfall in the initial assessment of this rare and aggressive malignancy on which the therapeutic approach greatly depends.

AB - A 64-year-old woman underwent initial 18F-FDG PET/CT staging for a suspicious endometrial mass, which showed high uptake in the endometrial mass and a focal uptake in a known left thyroid nodule. Histology revealed a high-grade large cell neuroendocrine carcinoma of the endometrium with FIGO (International Federation of Gynecology and Obstetrics) stage Ib. Further explorations revealed a synchronous thyroid metastasis. Patient then received adjuvant immunochemotherapy. This case showed a potential pitfall in the initial assessment of this rare and aggressive malignancy on which the therapeutic approach greatly depends.

KW - F-FDG PET/CT

KW - adjuvant therapy

KW - endometrium

KW - large cell neuroendocrine carci-noma

KW - thyroid metastasis

KW - uterus

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