TY - JOUR
T1 - Intratumoral Immunotherapy
T2 - Is It Ready for Prime Time?
AU - Ghosn, Mario
AU - Tselikas, Lambros
AU - Champiat, Stéphane
AU - Deschamps, Frederic
AU - Bonnet, Baptiste
AU - Carre, Émilie
AU - Testan, Marine
AU - Danlos, François Xavier
AU - Farhane, Siham
AU - Susini, Sandrine
AU - Suzzoni, Steve
AU - Ammari, Samy
AU - Marabelle, Aurélien
AU - De Baere, Thierry
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2023/8/1
Y1 - 2023/8/1
N2 - Purpose of Review: This review presents the rationale for intratumoral immunotherapy, technical considerations and safety. Clinical results from the latest trials are provided and discussed. Recent Findings: Intratumoral immunotherapy is feasible and safe in a wide range of cancer histologies and locations, including lung and liver. Studies mainly focused on multi-metastatic patients, with some positive trials such as T-VEC in melanoma, but evidence of clinical benefit is still lacking. Recent results showed improved outcomes in patients with a low tumor burden. Summary: Intratumoral immunotherapy can lower systemic toxicities and boost local and systemic immune responses. Several studies have proven the feasibility, repeatability, and safety of this approach, with some promising results in clinical trials. The clinical benefit might be improved in patients with a low tumor burden. Future clinical trials should focus on adequate timing of treatment delivery during the course of the disease, particularly in the neoadjuvant setting.
AB - Purpose of Review: This review presents the rationale for intratumoral immunotherapy, technical considerations and safety. Clinical results from the latest trials are provided and discussed. Recent Findings: Intratumoral immunotherapy is feasible and safe in a wide range of cancer histologies and locations, including lung and liver. Studies mainly focused on multi-metastatic patients, with some positive trials such as T-VEC in melanoma, but evidence of clinical benefit is still lacking. Recent results showed improved outcomes in patients with a low tumor burden. Summary: Intratumoral immunotherapy can lower systemic toxicities and boost local and systemic immune responses. Several studies have proven the feasibility, repeatability, and safety of this approach, with some promising results in clinical trials. The clinical benefit might be improved in patients with a low tumor burden. Future clinical trials should focus on adequate timing of treatment delivery during the course of the disease, particularly in the neoadjuvant setting.
KW - Immunotherapy
KW - Interventional radiology
KW - Intratumoral
KW - Oncology
UR - http://www.scopus.com/inward/record.url?scp=85156162691&partnerID=8YFLogxK
U2 - 10.1007/s11912-023-01422-4
DO - 10.1007/s11912-023-01422-4
M3 - Review article
AN - SCOPUS:85156162691
SN - 1523-3790
VL - 25
SP - 857
EP - 867
JO - Current Oncology Reports
JF - Current Oncology Reports
IS - 8
ER -