Involvement of the NF-κB pathway in the transforming properties of the TEL-Jak2 leukemogenic fusion protein

Susana Constantino Rosa Santos; Richard Monni; Isabelle Bouchaert; Olivier Bernard; Sylvie Gisselbrecht; Fabrice Gouilleux; Virginie Penard-Lacronique

doi:10.1016/S0014-5793(01)02452-8

Involvement of the NF-κB pathway in the transforming properties of the TEL-Jak2 leukemogenic fusion protein

Susana Constantino Rosa Santos, Richard Monni, Isabelle Bouchaert, Olivier Bernard, Sylvie Gisselbrecht, Fabrice Gouilleux, Virginie Penard-Lacronique

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

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Résumé

Constitutively active tyrosine kinases are frequently expressed in various types of human leukemias as the result of chromosomal translocations. The TEL-Jak2 fusion oncoprotein possesses transforming properties in both animal and cellular models, that are tightly dependent on Stat5 activation. In the IL-3-independent TEL-Jak2-transformed Ba/F3 cells, activation of the PI-3K/Akt pathway appears essential to cell proliferation. Here we report a sustained activation of NF-κB factors in Ba/F3 cells, which inhibition dramatically impairs cell viability, indicating that NF-κB signaling exerts a major role in the anti-apoptotic activities of TEL-Jak2 oncoprotein.

langue originale	Anglais
Pages (de - à)	148-152
Nombre de pages	5
journal	FEBS Letters
Volume	497
Numéro de publication	2-3
Les DOIs	https://doi.org/10.1016/S0014-5793(01)02452-8
état	Publié - 25 mai 2001

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10.1016/S0014-5793(01)02452-8

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title = "Involvement of the NF-κB pathway in the transforming properties of the TEL-Jak2 leukemogenic fusion protein",

abstract = "Constitutively active tyrosine kinases are frequently expressed in various types of human leukemias as the result of chromosomal translocations. The TEL-Jak2 fusion oncoprotein possesses transforming properties in both animal and cellular models, that are tightly dependent on Stat5 activation. In the IL-3-independent TEL-Jak2-transformed Ba/F3 cells, activation of the PI-3K/Akt pathway appears essential to cell proliferation. Here we report a sustained activation of NF-κB factors in Ba/F3 cells, which inhibition dramatically impairs cell viability, indicating that NF-κB signaling exerts a major role in the anti-apoptotic activities of TEL-Jak2 oncoprotein.",

keywords = "Leukemogenesis, NF-κB, TEL-Jak2 fusion protein",

author = "{Constantino Rosa Santos}, Susana and Richard Monni and Isabelle Bouchaert and Olivier Bernard and Sylvie Gisselbrecht and Fabrice Gouilleux and Virginie Penard-Lacronique",

note = "Funding Information: This work was supported in part by grants from the Ligue Nationale contre le Cancer (LNCC) and from the Fondation de France. R.M. is supported by a Minist{\`e}re de l{\textquoteright}Education Nationale de la Recherche et des Technologies (MENRT) fellowship and S.C.R.S. is supported by Praxis XXI.",

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T1 - Involvement of the NF-κB pathway in the transforming properties of the TEL-Jak2 leukemogenic fusion protein

AU - Constantino Rosa Santos, Susana

AU - Monni, Richard

AU - Bouchaert, Isabelle

AU - Bernard, Olivier

AU - Gisselbrecht, Sylvie

AU - Gouilleux, Fabrice

AU - Penard-Lacronique, Virginie

N1 - Funding Information: This work was supported in part by grants from the Ligue Nationale contre le Cancer (LNCC) and from the Fondation de France. R.M. is supported by a Ministère de l’Education Nationale de la Recherche et des Technologies (MENRT) fellowship and S.C.R.S. is supported by Praxis XXI.

PY - 2001/5/25

Y1 - 2001/5/25

N2 - Constitutively active tyrosine kinases are frequently expressed in various types of human leukemias as the result of chromosomal translocations. The TEL-Jak2 fusion oncoprotein possesses transforming properties in both animal and cellular models, that are tightly dependent on Stat5 activation. In the IL-3-independent TEL-Jak2-transformed Ba/F3 cells, activation of the PI-3K/Akt pathway appears essential to cell proliferation. Here we report a sustained activation of NF-κB factors in Ba/F3 cells, which inhibition dramatically impairs cell viability, indicating that NF-κB signaling exerts a major role in the anti-apoptotic activities of TEL-Jak2 oncoprotein.

AB - Constitutively active tyrosine kinases are frequently expressed in various types of human leukemias as the result of chromosomal translocations. The TEL-Jak2 fusion oncoprotein possesses transforming properties in both animal and cellular models, that are tightly dependent on Stat5 activation. In the IL-3-independent TEL-Jak2-transformed Ba/F3 cells, activation of the PI-3K/Akt pathway appears essential to cell proliferation. Here we report a sustained activation of NF-κB factors in Ba/F3 cells, which inhibition dramatically impairs cell viability, indicating that NF-κB signaling exerts a major role in the anti-apoptotic activities of TEL-Jak2 oncoprotein.

KW - Leukemogenesis

KW - NF-κB

KW - TEL-Jak2 fusion protein

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