Is the inflammasome relevant for epithelial cell function?

Patricia T. Santana, Jan Martel, Hsin Chih Lai, Jean Luc Perfettini, Jean M. Kanellopoulos, John D. Young, Robson Coutinho-Silva, David M. Ojcius

    Résultats de recherche: Contribution à un journalBrève enquêteRevue par des pairs

    35 Citations (Scopus)

    Résumé

    Inflammasomes are intracellular protein complexes that sense microbial components and damage of infected cells. Following activation by molecules released by pathogens or injured cells, inflammasomes activate caspase-1, allowing secretion of the pro-inflammatory cytokines IL-1β and IL-18 from innate immune cells. Inflammasomes are also expressed in epithelial cells, where their function has attracted less attention. Nonetheless, depending on the tissue, epithelial inflammasomes can mediate inflammation, wound healing, and pain sensitivity. We review here recent findings on inflammasomes found in epithelial tissues, highlighting the importance of these protein complexes in the response of epithelial tissues to microbial infections.

    langue originaleAnglais
    Pages (de - à)93-101
    Nombre de pages9
    journalMicrobes and Infection
    Volume18
    Numéro de publication2
    Les DOIs
    étatPublié - 1 févr. 2016

    Contient cette citation