TY - JOUR
T1 - JAM-B regulates maintenance of hematopoietic stem cells in the bone marrow
AU - Arcangeli, Marie Laure
AU - Frontera, Vincent
AU - Bardin, Florence
AU - Obrados, Elodie
AU - Adams, Susanne
AU - Chabannon, Christian
AU - Schiff, Claudine
AU - Mancini, Stephane J.C.
AU - Adams, Ralf H.
AU - Aurrand-Lions, Michel
PY - 2011/10/27
Y1 - 2011/10/27
N2 - In adult mammals, hematopoietic stem cells (HSCs) reside in the bone marrow (BM) and are maintained in a quiescent and undifferentiated state through adhesive interactions with specialized microenvironmental niches. Although junctional adhesion molecule-C (JAM-C) is expressed by HSCs, its function in adult hematopoiesis remains elusive. Here, we show that HSCs adhere to JAM-B expressed by BM stromal cells in a JAM-C dependent manner. The interaction regulates the interplay between HSCs and BM stromal cells as illustrated by the decreased pool of quiescent HSCs observed in jam-b deficient mice.We further show that this is probably because of alterations of BM stromal compartments and changes in SDF-1α BM content in jam-b-/- mice, suggesting that JAM-B is an active player in the maintenance of the BM stromal microenvironment.
AB - In adult mammals, hematopoietic stem cells (HSCs) reside in the bone marrow (BM) and are maintained in a quiescent and undifferentiated state through adhesive interactions with specialized microenvironmental niches. Although junctional adhesion molecule-C (JAM-C) is expressed by HSCs, its function in adult hematopoiesis remains elusive. Here, we show that HSCs adhere to JAM-B expressed by BM stromal cells in a JAM-C dependent manner. The interaction regulates the interplay between HSCs and BM stromal cells as illustrated by the decreased pool of quiescent HSCs observed in jam-b deficient mice.We further show that this is probably because of alterations of BM stromal compartments and changes in SDF-1α BM content in jam-b-/- mice, suggesting that JAM-B is an active player in the maintenance of the BM stromal microenvironment.
UR - http://www.scopus.com/inward/record.url?scp=80055078599&partnerID=8YFLogxK
U2 - 10.1182/blood-2010-12-323972
DO - 10.1182/blood-2010-12-323972
M3 - Article
C2 - 21868569
AN - SCOPUS:80055078599
SN - 0006-4971
VL - 118
SP - 4609
EP - 4619
JO - Blood
JF - Blood
IS - 17
ER -