JAM-B regulates maintenance of hematopoietic stem cells in the bone marrow

Marie Laure Arcangeli, Vincent Frontera, Florence Bardin, Elodie Obrados, Susanne Adams, Christian Chabannon, Claudine Schiff, Stephane J.C. Mancini, Ralf H. Adams, Michel Aurrand-Lions

    Résultats de recherche: Contribution à un journalArticleRevue par des pairs

    49 Citations (Scopus)

    Résumé

    In adult mammals, hematopoietic stem cells (HSCs) reside in the bone marrow (BM) and are maintained in a quiescent and undifferentiated state through adhesive interactions with specialized microenvironmental niches. Although junctional adhesion molecule-C (JAM-C) is expressed by HSCs, its function in adult hematopoiesis remains elusive. Here, we show that HSCs adhere to JAM-B expressed by BM stromal cells in a JAM-C dependent manner. The interaction regulates the interplay between HSCs and BM stromal cells as illustrated by the decreased pool of quiescent HSCs observed in jam-b deficient mice.We further show that this is probably because of alterations of BM stromal compartments and changes in SDF-1α BM content in jam-b-/- mice, suggesting that JAM-B is an active player in the maintenance of the BM stromal microenvironment.

    langue originaleAnglais
    Pages (de - à)4609-4619
    Nombre de pages11
    journalBlood
    Volume118
    Numéro de publication17
    Les DOIs
    étatPublié - 27 oct. 2011

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