Kar9 asymmetrical loading on spindle poles mediates proper spindle alignment in budding yeast

In the February 21 issue of Cell, Liakopoulos et al. demonstrate that asymmetrical loading of Kar9 onto astral microtubules (MTs) emanating from the budward-directed spindle pole ensures delivery of this spindle pole to the bud. Kar9 mediates alignment of the spindle with the cell polarity axis through a Myo2-dependent mechanism that reorients astral MTs toward the bud.