Ketosis versus carbotoxicity–metabolism determines the outcome of cancer immunotherapy

Aitziber Buqué; Lorenzo Galluzzi; Guido Kroemer

doi:10.1080/23723556.2020.1868266

Ketosis versus carbotoxicity–metabolism determines the outcome of cancer immunotherapy

Aitziber Buqué, Lorenzo Galluzzi, Guido Kroemer

Résultats de recherche: Contribution à un journal › !!Comment/debate

3 Citations (Scopus)

Résumé

Carbohydrate-rich diets have been consistently associated with detrimental effects for human health, including diabetes and obesity. Moreover, high glucose levels appear to mediate immunosuppressive effects in preclinical tumor models. Recent data from Ferrere and colleagues point to the intriguing possibility that carbotoxicity may originate from the abolition of ketosis.

langue originale	Anglais
Numéro d'article	1868266
journal	Molecular and Cellular Oncology
Volume	8
Numéro de publication	1
Les DOIs	https://doi.org/10.1080/23723556.2020.1868266
état	Publié - 1 janv. 2021

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10.1080/23723556.2020.1868266

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title = "Ketosis versus carbotoxicity–metabolism determines the outcome of cancer immunotherapy",

abstract = "Carbohydrate-rich diets have been consistently associated with detrimental effects for human health, including diabetes and obesity. Moreover, high glucose levels appear to mediate immunosuppressive effects in preclinical tumor models. Recent data from Ferrere and colleagues point to the intriguing possibility that carbotoxicity may originate from the abolition of ketosis.",

keywords = "3-hydroxybutyrate, CTLA4, PD-1, immune checkpoint inhibitors, ketogenic diet, sucrose",

author = "Aitziber Buqu{\'e} and Lorenzo Galluzzi and Guido Kroemer",

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year = "2021",

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AU - Galluzzi, Lorenzo

AU - Kroemer, Guido

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