TY - JOUR
T1 - L'échographie de contraste
T2 - Un nouvel outil d'évaluation des thérapies ciblées
AU - Lassau, N.
AU - Armand, J. P.
N1 - Funding Information:
3. Therasse P, Arbuck SG, Eisenhauer EA, et al. (2000) New guidelines to evaluate the response to treatment in solid tumours. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 92 (3): 205-16
PY - 2006/11/1
Y1 - 2006/11/1
N2 - The early functional evaluation of new targeted therapies in oncology is a major goal of functional imaging. At present, technical advances in Doppler ultrasonography allow the detection of neovascularization in superficial and deep malignant tumours in order to evaluate the effectiveness of new treatments such as antiangiogenic drugs. Injecting contrast agents increases the effectiveness of this kind of therapy, and developments in perfusion software have optimized detection. It is possible to detect slow flow in tumour microvessels. Treatment response can be predicted early, based on changes in vascularization before volume modification, by calculating peak intensity, time to peak intensity, area under the curve, and the wash-in slope coefficient.
AB - The early functional evaluation of new targeted therapies in oncology is a major goal of functional imaging. At present, technical advances in Doppler ultrasonography allow the detection of neovascularization in superficial and deep malignant tumours in order to evaluate the effectiveness of new treatments such as antiangiogenic drugs. Injecting contrast agents increases the effectiveness of this kind of therapy, and developments in perfusion software have optimized detection. It is possible to detect slow flow in tumour microvessels. Treatment response can be predicted early, based on changes in vascularization before volume modification, by calculating peak intensity, time to peak intensity, area under the curve, and the wash-in slope coefficient.
KW - Antiangiogenic drugs
KW - Contrast agents
KW - Doppler ultrasonography
UR - http://www.scopus.com/inward/record.url?scp=33846066762&partnerID=8YFLogxK
U2 - 10.1007/s10269-006-0538-4
DO - 10.1007/s10269-006-0538-4
M3 - Article
AN - SCOPUS:33846066762
SN - 1292-3818
VL - 8
SP - 850
EP - 855
JO - Oncologie
JF - Oncologie
IS - 9
ER -