TY - JOUR
T1 - Laparoscopic versus open liver resection for hepatocellular carcinoma in elderly patients
T2 - a propensity score matching analysis
AU - Delvecchio, Antonella
AU - Conticchio, Maria
AU - Riccelli, Umberto
AU - Ferraro, Valentina
AU - Ratti, Francesca
AU - Gelli, Maximiliano
AU - Anelli, Ferdinando M.
AU - Laurent, Alexis
AU - Vitali, Giulio C.
AU - Magistri, Paolo
AU - Assirati, Giacomo
AU - Felli, Emanuele
AU - Wakabayashi, Taiga
AU - Pessaux, Patrick
AU - Piardi, Tullio
AU - Di Benedetto, Fabrizio
AU - de'Angelis, Nicola
AU - Briceño-Delgado, Javier
AU - Adam, Rene
AU - Cherqui, Daniel
AU - Aldrighetti, Luca
AU - Memeo, Riccardo
N1 - Publisher Copyright:
© 2021 International Hepato-Pancreato-Biliary Association Inc.
PY - 2022/6/1
Y1 - 2022/6/1
N2 - Background: Surgical resection is a first-line curative option for hepatocellular carcinoma, but its role is still unclear in elderly patients. The aim of our study was to compare short- and long-term outcomes of laparoscopic and open liver resection in elderly patients with hepatocellular carcinoma. Methods: The study included 665 consecutive hepatocellular carcinoma liver resection cases in patients with ≥70 years of age treated in eight European hospital centres. Patients were divided into laparoscopic and open liver resection groups. Perioperative and long-term outcomes were compared between these groups. Results: After a 1:1 propensity score matching, 219 patients were included in each group. Clavien-Dindo grades III/IV (6 vs. 20%, p = 0.04) were lower in the laparoscopic than in the open matched group. Hospital stay was shorter in the laparoscopic than in the open matched group (5 vs. 7 days, p < 0.001). There were no significant differences between laparoscopic and open groups regarding overall survival and disease-free survival at 1-, 3- and 5- year periods. Conclusion: Laparoscopic liver resection for hepatocellular carcinoma is associated with good short-term outcomes in patients with ≥70 years of age compared to open liver resection. Laparoscopic liver resection is safe and feasible in elderly patients with hepatocellular carcinoma.
AB - Background: Surgical resection is a first-line curative option for hepatocellular carcinoma, but its role is still unclear in elderly patients. The aim of our study was to compare short- and long-term outcomes of laparoscopic and open liver resection in elderly patients with hepatocellular carcinoma. Methods: The study included 665 consecutive hepatocellular carcinoma liver resection cases in patients with ≥70 years of age treated in eight European hospital centres. Patients were divided into laparoscopic and open liver resection groups. Perioperative and long-term outcomes were compared between these groups. Results: After a 1:1 propensity score matching, 219 patients were included in each group. Clavien-Dindo grades III/IV (6 vs. 20%, p = 0.04) were lower in the laparoscopic than in the open matched group. Hospital stay was shorter in the laparoscopic than in the open matched group (5 vs. 7 days, p < 0.001). There were no significant differences between laparoscopic and open groups regarding overall survival and disease-free survival at 1-, 3- and 5- year periods. Conclusion: Laparoscopic liver resection for hepatocellular carcinoma is associated with good short-term outcomes in patients with ≥70 years of age compared to open liver resection. Laparoscopic liver resection is safe and feasible in elderly patients with hepatocellular carcinoma.
UR - http://www.scopus.com/inward/record.url?scp=85119421223&partnerID=8YFLogxK
U2 - 10.1016/j.hpb.2021.10.024
DO - 10.1016/j.hpb.2021.10.024
M3 - Article
C2 - 34815189
AN - SCOPUS:85119421223
SN - 1365-182X
VL - 24
SP - 933
EP - 941
JO - HPB
JF - HPB
IS - 6
ER -