L'apoptose: mécanismes moléculaires.

E. Solary

Résultats de recherche: Contribution à un journalArticle 'review'Revue par des pairs

5 Citations (Scopus)

Résumé

Apoptosis is a genetically programmed cell death that is required for morphogenesis during embryogenic development and for tissue homeostasis in adult organisms. In most cases, apoptosis involves cytochrome c release from mitochondria. In the cytosol, cytochrome c combines with APAF-1 in the presence of ATP to activate caspase-9 that, in turn, activates effectors caspases such as caspase-3. Bcl-2 and related proteins control cytochrome c release from the mitochondria whereas IAP (for Inhibitor of APoptosis) molecules modulate the activity of caspases. Plasma membrane receptors such as Fas (CD95, APO-1), characterized by a so-called "death domain" in their cytoplasmic domain, can activate the caspase cascade through adaptator molecules such as FADD (Fas-Associated protein with a Death Domain). Dysregulation of the apoptotic machinery plays a role in the pathogenesis of various diseases and molecules involved in cell death pathways are potential therapeutic targets in immunologic, neurologic, cancer, infectious and inflammatory diseases.

Titre traduit de la contributionApoptosis: molecular mechanisms
langue originaleFrançais
Pages (de - à)1065-1076
Nombre de pages12
journalComptes rendus des séances de la Société de biologie et de ses filiales
Volume192
Numéro de publication6
étatPublié - 1 janv. 1998
Modification externeOui

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