Résumé
Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ∼9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborative Oncological Gene-environment Study, COGS) and used a custom Illumina iSelect genotyping array, iCOGS, comprising more than 200,000 SNPs. We identified SNPs at 41 new breast cancer susceptibility loci at genome-wide significance (P < 5 × 10 -8). Further analyses suggest that more than 1,000 additional loci are involved in breast cancer susceptibility.
langue originale | Anglais |
---|---|
Pages (de - à) | 353-361 |
Nombre de pages | 9 |
journal | Nature Genetics |
Volume | 45 |
Numéro de publication | 4 |
Les DOIs | |
état | Publié - 1 avr. 2013 |
Modification externe | Oui |
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Dans: Nature Genetics, Vol 45, Numéro 4, 01.04.2013, p. 353-361.
Résultats de recherche: Contribution à un journal › Article › Revue par des pairs
TY - JOUR
T1 - Large-scale genotyping identifies 41 new loci associated with breast cancer risk
AU - Michailidou, Kyriaki
AU - Hall, Per
AU - Gonzalez-Neira, Anna
AU - Ghoussaini, Maya
AU - Dennis, Joe
AU - Milne, Roger L.
AU - Schmidt, Marjanka K.
AU - Chang-Claude, Jenny
AU - Bojesen, Stig E.
AU - Bolla, Manjeet K.
AU - Wang, Qin
AU - Dicks, Ed
AU - Lee, Andrew
AU - Turnbull, Clare
AU - Rahman, Nazneen
AU - Fletcher, Olivia
AU - Peto, Julian
AU - Gibson, Lorna
AU - Dos Santos Silva, Isabel
AU - Nevanlinna, Heli
AU - Muranen, Taru A.
AU - Aittomäki, Kristiina
AU - Blomqvist, Carl
AU - Czene, Kamila
AU - Irwanto, Astrid
AU - Liu, Jianjun
AU - Waisfisz, Quinten
AU - Meijers-Heijboer, Hanne
AU - Adank, Muriel
AU - Van Der Luijt, Rob B.
AU - Hein, Rebecca
AU - Dahmen, Norbert
AU - Beckman, Lars
AU - Meindl, Alfons
AU - Schmutzler, Rita K.
AU - Müller-Myhsok, Bertram
AU - Lichtner, Peter
AU - Hopper, John L.
AU - Southey, Melissa C.
AU - Makalic, Enes
AU - Schmidt, Daniel F.
AU - Uitterlinden, Andre G.
AU - Hofman, Albert
AU - Hunter, David J.
AU - Chanock, Stephen J.
AU - Vincent, Daniel
AU - Bacot, François
AU - Tessier, Daniel C.
AU - Canisius, Sander
AU - Wessels, Lodewyk F.A.
AU - Haiman, Christopher A.
AU - Shah, Mitul
AU - Luben, Robert
AU - Brown, Judith
AU - Luccarini, Craig
AU - Schoof, Nils
AU - Humphreys, Keith
AU - Li, Jingmei
AU - Nordestgaard, Børge G.
AU - Nielsen, Sune F.
AU - Flyger, Henrik
AU - Couch, Fergus J.
AU - Wang, Xianshu
AU - Vachon, Celine
AU - Stevens, Kristen N.
AU - Lambrechts, Diether
AU - Moisse, Matthieu
AU - Paridaens, Robert
AU - Christiaens, Marie Rose
AU - Rudolph, Anja
AU - Nickels, Stefan
AU - Flesch-Janys, Dieter
AU - Johnson, Nichola
AU - Aitken, Zoe
AU - Aaltonen, Kirsimari
AU - Heikkinen, Tuomas
AU - Broeks, Annegien
AU - Veer, Laura J.Van T.
AU - Van Der Schoot, C. Ellen
AU - Guénel, Pascal
AU - Truong, Thérèse
AU - Laurent-Puig, Pierre
AU - Menegaux, Florence
AU - Marme, Frederik
AU - Schneeweiss, Andreas
AU - Sohn, Christof
AU - Burwinkel, Barbara
AU - Zamora, M. Pilar
AU - Perez, Jose Ignacio Arias
AU - Pita, Guillermo
AU - Alonso, M. Rosario
AU - Cox, Angela
AU - Brock, Ian W.
AU - Cross, Simon S.
AU - Reed, Malcolm W.R.
AU - Sawyer, Elinor J.
AU - Tomlinson, Ian
AU - Kerin, Michael J.
AU - Miller, Nicola
AU - Henderson, Brian E.
AU - Schumacher, Fredrick
AU - Le Marchand, Loic
AU - Andrulis, Irene L.
AU - Knight, Julia A.
AU - Glendon, Gord
AU - Mulligan, Anna Marie
AU - Lindblom, Annika
AU - Margolin, Sara
AU - Hooning, Maartje J.
AU - Hollestelle, Antoinette
AU - Van Den Ouweland, Ans M.W.
AU - Jager, Agnes
AU - Bui, Quang M.
AU - Stone, Jennifer
AU - Dite, Gillian S.
AU - Apicella, Carmel
AU - Tsimiklis, Helen
AU - Giles, Graham G.
AU - Severi, Gianluca
AU - Baglietto, Laura
AU - Fasching, Peter A.
AU - Haeberle, Lothar
AU - Ekici, Arif B.
AU - Beckmann, Matthias W.
AU - Brenner, Hermann
AU - Müller, Heiko
AU - Arndt, Volker
AU - Stegmaier, Christa
AU - Swerdlow, Anthony
AU - Ashworth, Alan
AU - Orr, Nick
AU - Jones, Michael
AU - Figueroa, Jonine
AU - Lissowska, Jolanta
AU - Brinton, Louise
AU - Goldberg, Mark S.
AU - Labrèche, France
AU - Dumont, Martine
AU - Winqvist, Robert
AU - Pylkäs, Katri
AU - Jukkola-Vuorinen, Arja
AU - Grip, Mervi
AU - Brauch, Hiltrud
AU - Hamann, Ute
AU - Brüning, Thomas
AU - Radice, Paolo
AU - Peterlongo, Paolo
AU - Manoukian, Siranoush
AU - Bonanni, Bernardo
AU - Devilee, Peter
AU - Tollenaar, Rob A.E.M.
AU - Seynaeve, Caroline
AU - Van Asperen, Christi J.
AU - Jakubowska, Anna
AU - Lubinski, Jan
AU - Jaworska, Katarzyna
AU - Durda, Katarzyna
AU - Mannermaa, Arto
AU - Kataja, Vesa
AU - Kosma, Veli Matti
AU - Hartikainen, Jaana M.
AU - Bogdanova, Natalia V.
AU - Antonenkova, Natalia N.
AU - Dörk, Thilo
AU - Kristensen, Vessela N.
AU - Anton-Culver, Hoda
AU - Slager, Susan
AU - Toland, Amanda E.
AU - Edge, Stephen
AU - Fostira, Florentia
AU - Kang, Daehee
AU - Yoo, Keun Young
AU - Noh, Dong Young
AU - Matsuo, Keitaro
AU - Ito, Hidemi
AU - Iwata, Hiroji
AU - Sueta, Aiko
AU - Wu, Anna H.
AU - Tseng, Chiu Chen
AU - Van Den Berg, David
AU - Stram, Daniel O.
AU - Shu, Xiao Ou
AU - Lu, Wei
AU - Gao, Yu Tang
AU - Cai, Hui
AU - Teo, Soo Hwang
AU - Yip, Cheng Har
AU - Phuah, Sze Yee
AU - Cornes, Belinda K.
AU - Hartman, Mikael
AU - Miao, Hui
AU - Lim, Wei Yen
AU - Sng, Jen Hwei
AU - Muir, Kenneth
AU - Lophatananon, Artitaya
AU - Stewart-Brown, Sarah
AU - Siriwanarangsan, Pornthep
AU - Shen, Chen Yang
AU - Hsiung, Chia Ni
AU - Wu, Pei Ei
AU - Ding, Shian Ling
AU - Sangrajrang, Suleeporn
AU - Gaborieau, Valerie
AU - Brennan, Paul
AU - McKay, James
AU - Blot, William J.
AU - Signorello, Lisa B.
AU - Cai, Qiuyin
AU - Zheng, Wei
AU - Deming-Halverson, Sandra
AU - Shrubsole, Martha
AU - Long, Jirong
AU - Simard, Jacques
AU - Garcia-Closas, Montse
AU - Pharoah, Paul D.P.
AU - Chenevix-Trench, Georgia
AU - Dunning, Alison M.
AU - Benitez, Javier
AU - Easton, Douglas F.
PY - 2013/4/1
Y1 - 2013/4/1
N2 - Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ∼9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborative Oncological Gene-environment Study, COGS) and used a custom Illumina iSelect genotyping array, iCOGS, comprising more than 200,000 SNPs. We identified SNPs at 41 new breast cancer susceptibility loci at genome-wide significance (P < 5 × 10 -8). Further analyses suggest that more than 1,000 additional loci are involved in breast cancer susceptibility.
AB - Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ∼9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborative Oncological Gene-environment Study, COGS) and used a custom Illumina iSelect genotyping array, iCOGS, comprising more than 200,000 SNPs. We identified SNPs at 41 new breast cancer susceptibility loci at genome-wide significance (P < 5 × 10 -8). Further analyses suggest that more than 1,000 additional loci are involved in breast cancer susceptibility.
UR - http://www.scopus.com/inward/record.url?scp=84875703379&partnerID=8YFLogxK
U2 - 10.1038/ng.2563
DO - 10.1038/ng.2563
M3 - Article
C2 - 23535729
AN - SCOPUS:84875703379
SN - 1061-4036
VL - 45
SP - 353
EP - 361
JO - Nature Genetics
JF - Nature Genetics
IS - 4
ER -