TY - JOUR
T1 - Late Effects in Childhood Cancer Survivors
T2 - Early Studies, Survivor Cohorts, and Significant Contributions to the Field of Late Effects
AU - Norsker, Filippa Nyboe
AU - Pedersen, Camilla
AU - Armstrong, Gregory T.
AU - Robison, Leslie L.
AU - McBride, Mary L.
AU - Hawkins, Michael
AU - Kuehni, Claudia E.
AU - de Vathaire, Florent
AU - Berbis, Julie
AU - Kremer, Leontien C.
AU - Haupt, Riccardo
AU - Kenborg, Line
AU - Winther, Jeanette Falck
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/12/1
Y1 - 2020/12/1
N2 - With improvement in cure of childhood cancer came the responsibility to investigate the long-term morbidity and mortality associated with the treatments accountable for this increase in survival. Several large cohorts of childhood cancer survivors have been established throughout Europe and North America to facilitate research on long-term complications of cancer treatment. The cohorts have made significant contributions to the understanding of early mortality, somatic late complications, and psychosocial outcomes among childhood cancer survivors, which has been translated into the design of new treatment protocols for pediatric cancers, with the goal to reduce the potential risk and severity of late effects.
AB - With improvement in cure of childhood cancer came the responsibility to investigate the long-term morbidity and mortality associated with the treatments accountable for this increase in survival. Several large cohorts of childhood cancer survivors have been established throughout Europe and North America to facilitate research on long-term complications of cancer treatment. The cohorts have made significant contributions to the understanding of early mortality, somatic late complications, and psychosocial outcomes among childhood cancer survivors, which has been translated into the design of new treatment protocols for pediatric cancers, with the goal to reduce the potential risk and severity of late effects.
KW - Cancer research
KW - Childhood cancer survivors
KW - Late effects
KW - Long-term complications
KW - Survivor cohorts
UR - http://www.scopus.com/inward/record.url?scp=85094179678&partnerID=8YFLogxK
U2 - 10.1016/j.pcl.2020.07.002
DO - 10.1016/j.pcl.2020.07.002
M3 - Review article
C2 - 33131533
AN - SCOPUS:85094179678
SN - 0031-3955
VL - 67
SP - 1033
EP - 1049
JO - Pediatric Clinics of North America
JF - Pediatric Clinics of North America
IS - 6
ER -