Le récepteur du facteur de croissance épidermique (EGF) dans les carcinomes des voies aérodigestives supérieures

J. Bourhis; Y. G. Tao; P. Zhang; E. Deutsch

doi:10.1684/bdc.2007.0437

Le récepteur du facteur de croissance épidermique (EGF) dans les carcinomes des voies aérodigestives supérieures

J. Bourhis, Y. G. Tao, P. Zhang, E. Deutsch

Résultats de recherche: Contribution à un journal › Article 'review' › Revue par des pairs

1 Citation (Scopus)

Résumé

EGFR is frequently overexpressed and is associated with a poor prognosis in head and neck carcinoma (HNC). Among the biological and cellular effects resulting from EGFR targeting, there are the possibilities to restore apoptotic capacities and to reduce DNA-repair activity, to inhibit angiogenesis and tumor cell migration. This suggests the potential interest of the combination between anti-EGFR drugs and cytotoxic agents, especially ionizing radiation with promising results obtained at the clinical level in locally advanced HNC.

Titre traduit de la contribution	Epidermal growth factor receptor (EGF) in head-and-neck cancers
langue originale	Français
Pages (de - à)	F189-F191
journal	Bulletin du Cancer
Volume	94
Numéro de publication	SUPPL. 7
Les DOIs	https://doi.org/10.1684/bdc.2007.0437
état	Publié - 1 sept. 2007

mots-clés

Association with radiotherapy and chemotherapy
EGFR
Targeted therapy

Accès au document

10.1684/bdc.2007.0437

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AU - Zhang, P.

AU - Deutsch, E.

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AB - EGFR is frequently overexpressed and is associated with a poor prognosis in head and neck carcinoma (HNC). Among the biological and cellular effects resulting from EGFR targeting, there are the possibilities to restore apoptotic capacities and to reduce DNA-repair activity, to inhibit angiogenesis and tumor cell migration. This suggests the potential interest of the combination between anti-EGFR drugs and cytotoxic agents, especially ionizing radiation with promising results obtained at the clinical level in locally advanced HNC.

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