Leptin-Producing Oncolytic Virus Makes Tumor-Infiltrating T Cells Fit, Not Fat

Guido Kroemer; Laurence Zitvogel

doi:10.1016/j.immuni.2019.08.010

Leptin-Producing Oncolytic Virus Makes Tumor-Infiltrating T Cells Fit, Not Fat

Guido Kroemer, Laurence Zitvogel

Résultats de recherche: Contribution à un journal › Brève enquête › Revue par des pairs

5 Citations (Scopus)

Résumé

Effective anticancer immunosurveillance after oncolytic viral infection is often hindered by the defective metabolic function of tumor-infiltrating lymphocytes (TILs). A recent paper by Rivadeneira et al. demonstrates that intratumoral delivery of leptin by a recombinant oncolytic vaccinia virus can metabolically enhance TIL effector and memory functions through improved mitochondrial oxidative phosphorylation, thereby enhancing therapeutic efficacy.

langue originale	Anglais
Pages (de - à)	423-425
Nombre de pages	3
journal	Immunity
Volume	51
Numéro de publication	3
Les DOIs	https://doi.org/10.1016/j.immuni.2019.08.010
état	Publié - 17 sept. 2019

Accès au document

10.1016/j.immuni.2019.08.010

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title = "Leptin-Producing Oncolytic Virus Makes Tumor-Infiltrating T Cells Fit, Not Fat",

abstract = "Effective anticancer immunosurveillance after oncolytic viral infection is often hindered by the defective metabolic function of tumor-infiltrating lymphocytes (TILs). A recent paper by Rivadeneira et al. demonstrates that intratumoral delivery of leptin by a recombinant oncolytic vaccinia virus can metabolically enhance TIL effector and memory functions through improved mitochondrial oxidative phosphorylation, thereby enhancing therapeutic efficacy.",

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