Les cancers des voies aérodigestives supérieures associés aux papillomavirus

Cécile Badoual, Hélène Péré, Hélène Roussel, Ali Si Mohamed, Éric Tartour

Résultats de recherche: Contribution à un journalArticleRevue par des pairs

4 Citations (Scopus)

Résumé

Carcinomas of the aerodigestive tract are most often secondary to alcohol and tobacco intoxication. However, it is shown that the oncogenic human papillomavirus (HPV) have an increasing role in the carcinogenesis of these cancers. Patients with HPV+ carcinoma are generally younger and not alcohol and tobacco users. These carcinomas are mainly localized in the oropharynx and in particular at the tonsil. HPV is found in 40 to 90 % of the cancers in the oropharynx, depending on the country. These HPV+ carcinomas have a better prognosis with better radio or chemosensitivity. To date, no change of treatment is recommended, however, several trials are underway. Preventive vaccination of boys is a real public health issue, especially since it is recommended in some countries. Moreover, a better understanding of the tumor microenvironment will ultimately offer therapeutic vaccination.

Titre traduit de la contributionCancers of the upper aerodigestive tract associated with human papillomavirus
langue originaleFrançais
Pages (de - à)83-88
Nombre de pages6
journalMedecine/Sciences
Volume29
Numéro de publication1
Les DOIs
étatPublié - 1 janv. 2013
Modification externeOui

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