Leucémies aiguës myéloïdes secondaires aux traitements: Implication des mécanismes de réparation de l'ADN

Romain Guièze, Aurélie Ravinet, Éric Hermet, Yassine Maliki, Stéphane De Botton, Jacques Olivier Bay

    Résultats de recherche: Contribution à un journalArticle 'review'Revue par des pairs

    Résumé

    The survival improvement of patients treated with chemotherapy or radiotherapy for malignancies are increasing therapy-related acute myeloid leukemia (t-AML). It was thought to be the direct consequence of genetic events induced by such treatments.We here review the mechanisms of specific chemotherapy-related DNA damage inducing the chromosomal or genomic abnormalities characteristic of t-AML.We also focus on how such aberrations could initiate or participate to leukemogenesis. However, only a part of patients exposed to cytotoxic therapy is developing t-AML, suggesting that some genetic predisposition may be involved such as polymorphisms in genes related to DNA repair.

    Titre traduit de la contributionTherapy-related acute myeloid leukemia: Role of DNA repair
    langue originaleFrançais
    Pages (de - à)247-255
    Nombre de pages9
    journalBulletin du Cancer
    Volume98
    Numéro de publication3
    Les DOIs
    étatPublié - 1 janv. 2011

    mots-clés

    • DNA repair
    • Leukemogenesis
    • Therapy-related acute myeloid leukemia

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