TY - JOUR
T1 - Leukocyte telomere length in relation to pancreatic cancer risk
T2 - A prospective study
AU - Campa, Daniele
AU - Mergarten, Bjöorn
AU - De Vivo, Immaculata
AU - Boutron-Ruault, Marie Christine
AU - Racine, Antoine
AU - Severi, Gianluca
AU - Nieters, Alexandra
AU - Katzke, Verena A.
AU - Trichopoulou, Antonia
AU - Yiannakouris, Nikos
AU - Trichopoulos, Dimitrios
AU - Boeing, Heiner
AU - Quirós, J. Ramón
AU - Duell, Eric J.
AU - Molina-Montes, Esther
AU - Huerta, José María
AU - Ardanaz, Eva
AU - Dorronsoro, Miren
AU - Khaw, Kay Tee
AU - Wareham, Nicholas
AU - Travis, Ruth C.
AU - Palli, Domenico
AU - Pala, Valeria
AU - Tumino, Rosario
AU - Naccarati, Alessio
AU - Panico, Salvatore
AU - Vineis, Paolo
AU - Riboli, Elio
AU - Siddiq, Afshan
AU - Bueno-de-Mesquita, H. B.
AU - Peeters, Petra H.
AU - Nilsson, Peter M.
AU - Sund, Malin
AU - Ye, Weimin
AU - Lund, Eiliv
AU - Jareid, Mie
AU - Weiderpass, Elisabete
AU - Duarte-Salles, Talita
AU - Kong, So Yeon
AU - Stepien, Magdalena
AU - Canzian, Federico
AU - Kaaks, Rudolf
N1 - Publisher Copyright:
©2014 AACR.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Background: Several studies have examined leukocyte telomere length (LTL) as a possible predictor for cancer at various organ sites. The hypothesis originally motivating many of these studies was that shorter telomeres would be associated with an increase in cancer risk; the results of epidemiologic studies have been inconsistent, however, and suggested positive, negative, or null associations. Two studies have addressed the association of LTL in relation to pancreatic cancer risk and the results are contrasting. Methods: We measured LTL in a prospective study of 331 pancreatic cancer cases and 331 controls in the context of the European Prospective Investigation into Cancer and Nutrition (EPIC). Results: We observed that the mean LTL was higher in cases (0.59 ± 0.20) than in controls (0.57 ± 0.17), although this difference was not statistically significant (P = 0.07), and a basic logistic regression model showed no association of LTL with pancreas cancer risk. When adjusting for levels of HbA1c and C-peptide, however, there was a weakly positive association between longer LTL and pancreatic cancer risk [OR, 1.13; 95% confidence interval (CI), 1.01-1.27]. Additional analyses by cubic spline regression suggested a possible nonlinear relationship between LTL and pancreatic cancer risk (P = 0.022), with a statistically nonsignificant increase in risk at very low LTL, as well as a significant increase at high LTL. Conclusion: Taken together, the results from our study do not support LTL as a uniform and strong predictor of pancreatic cancer. Impact: The results of this article can provide insights into telomere dynamics and highlight the complex relationship between LTL and pancreatic cancer risk.
AB - Background: Several studies have examined leukocyte telomere length (LTL) as a possible predictor for cancer at various organ sites. The hypothesis originally motivating many of these studies was that shorter telomeres would be associated with an increase in cancer risk; the results of epidemiologic studies have been inconsistent, however, and suggested positive, negative, or null associations. Two studies have addressed the association of LTL in relation to pancreatic cancer risk and the results are contrasting. Methods: We measured LTL in a prospective study of 331 pancreatic cancer cases and 331 controls in the context of the European Prospective Investigation into Cancer and Nutrition (EPIC). Results: We observed that the mean LTL was higher in cases (0.59 ± 0.20) than in controls (0.57 ± 0.17), although this difference was not statistically significant (P = 0.07), and a basic logistic regression model showed no association of LTL with pancreas cancer risk. When adjusting for levels of HbA1c and C-peptide, however, there was a weakly positive association between longer LTL and pancreatic cancer risk [OR, 1.13; 95% confidence interval (CI), 1.01-1.27]. Additional analyses by cubic spline regression suggested a possible nonlinear relationship between LTL and pancreatic cancer risk (P = 0.022), with a statistically nonsignificant increase in risk at very low LTL, as well as a significant increase at high LTL. Conclusion: Taken together, the results from our study do not support LTL as a uniform and strong predictor of pancreatic cancer. Impact: The results of this article can provide insights into telomere dynamics and highlight the complex relationship between LTL and pancreatic cancer risk.
UR - http://www.scopus.com/inward/record.url?scp=84918835252&partnerID=8YFLogxK
U2 - 10.1158/1055-9965.EPI-14-0247
DO - 10.1158/1055-9965.EPI-14-0247
M3 - Article
C2 - 25103821
AN - SCOPUS:84918835252
SN - 1055-9965
VL - 23
SP - 2447
EP - 2454
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 11
ER -