Life years lost by childhood cancer treatment and health related late effects among childhood cancer survivors

Thibaud Charrier, Nadia Haddy, Brice Fresneau, Boris Schwartz, Neige Journy, Charlotte Demoor-Goldschmidt, Ibrahima Diallo, Isabelle Aerts, François Doz, Vincent Souchard, Giao Vu-Bezin, Anne Laprie, Sarah Lemler, Véronique Letort, Carole Rubino, Kaniav Kamary, Naïla Myriam Aba, Claire Ducos, Médéa Locquet, Florent de VathaireRodrigue S. Allodji, Aurélien Latouche

    Résultats de recherche: Contribution à un journalArticleRevue par des pairs

    Résumé

    Background: Identifying risk factors contributing the most to mortality of childhood cancer survivors is essential to guide harm reduction efforts in childhood cancer treatments, and long-term follow-up of childhood cancer survivors. Methods: We assessed Life Years Lost from childhood cancer treatments and their health-related late effects among the French Childhood Cancer Survivors Study, a cohort of 7670 5-year childhood cancer survivors. Using a landmark strategy, we also assessed time-varying effects of risk factors, and how the multi-morbidity affects life years lost. Results: We found subsequent malignant neoplasm (9.0 years [95 %CI: 4.3–13.7]), severe cardiac disease (8.0 years [95 %CI: 1.2–14.9]), and the use of radiotherapy (6.0 years [95 %CI: 4.7–7.3]) to be the highest contributors to Life Years Lost among childhood cancer survivors. We found no interaction impact on life years lost between health related late effects considered. Conclusions: Those findings suggest that radiotherapy is the root cause of early mortality among childhood cancer survivors. Moreover patients experiencing a subsequent malignant neoplasm or a cardiac disease should be monitored closely after the event, as comorbidity is common and causes premature deaths.

    langue originaleAnglais
    Numéro d'article102692
    journalCancer Epidemiology
    Volume93
    Les DOIs
    étatPublié - 1 déc. 2024

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