Liver toxicity in the era of immune checkpoint inhibitors: A practical approach

Carmen Belli, Massimo Zuin, Luca Mazzarella, Dario Trapani, Paolo D'Amico, Elena Guerini-Rocco, Bruno Achutti Duso, Giuseppe Curigliano

Résultats de recherche: Contribution à un journalArticle 'review'Revue par des pairs

19 Citations (Scopus)

Résumé

Immune checkpoint inhibitors have revolutionized the cancer treatment with an approved efficacy in different solid tumors and hematologic malignancies. These agents are increasing the indication in cancer treatment, but can be associated with serious immune-related adverse effects (IRAEs). Dermatologic and gastrointestinal toxicities are the most common IRAE followed by endocrinopathies with a different time of occurrence. Rarely cases of gastrointestinal toxicities are observed almost 2 years after initiation of the therapy. In this review we focus on liver toxicity related to these immunotherapeutic agents for which the largest amount of safety data is available. The management of drug-induced liver toxicity is very complicated and in same cases may take a long period of time to be resolved. A prompt recognition of liver IRAEs and an appropriate management of this event, requiring close collaboration with other specialist figures, could improve its treatment with evident implication on the efficacy of the therapy.

langue originaleAnglais
Pages (de - à)125-129
Nombre de pages5
journalCritical Reviews in Oncology/Hematology
Volume132
Les DOIs
étatPublié - 1 déc. 2018
Modification externeOui

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