Localisation secondaire atypique au " sein " des cancers bronchiques

In the context of bronchial cancers, the most frequent sites for metastases tooccur are the lung, bone, brain, liver and adrenal glands. However, metastasis to other sitesdoes additionally occur and this might be influenced by the biological characteristics of thetumour.Observation.-We report the case of a 54-year-old woman with a primary bronchial adeno-carcinoma with an EML4-ALK translocation. During her treatment with crizotinib, the patientdeveloped a lesion in her right breast. The initial pathological diagnosis was of an invasiveductal adenocarcinoma of the breast. However, an additional immuno-histochemical analysisrevealed it to be a metastasis from her bronchial tumour.Conclusion.-This case is an illustration that, in the context of a lung cancer with ALK rearran-gement, synchronous or secondary lesions must be interpreted with caution. Specific biologicalanalysis-ALK immunohistochemistry or FISH-must be performed to confirm a primary ormetastatic origin for these lesions.