TY - JOUR
T1 - Long survival in a child with a mutated K27M-H3.3 pilocytic astrocytoma
AU - Hochart, Audrey
AU - Escande, Fabienne
AU - Rocourt, Nathalie
AU - Grill, Jacques
AU - Koubi-Pick, Valérie
AU - Beaujot, Juliette
AU - Meignan, Samuel
AU - Vinchon, Matthieu
AU - Maurage, Claude Alain
AU - Leblond, Pierre
N1 - Publisher Copyright:
© 2015 The Authors.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - We report the first case of a child with a H3F3A K27M mutated pilocytic astrocytoma, who presented with a 10 years survival, and underwent spontaneous malignant transformation. The complex tumoral chromosomal rearrangements were consistent for genomic instability and for the histopathological features of malignant transformation into glioblastoma. H3F3A K27M mutations are rarely observed in benign neoplasms and may be associated with an adverse outcome. This mutation might not be the major driver that led to the onset of tumorigenesis, and we could consider that the associated TP53 mutation, would be required for malignant transformation.
AB - We report the first case of a child with a H3F3A K27M mutated pilocytic astrocytoma, who presented with a 10 years survival, and underwent spontaneous malignant transformation. The complex tumoral chromosomal rearrangements were consistent for genomic instability and for the histopathological features of malignant transformation into glioblastoma. H3F3A K27M mutations are rarely observed in benign neoplasms and may be associated with an adverse outcome. This mutation might not be the major driver that led to the onset of tumorigenesis, and we could consider that the associated TP53 mutation, would be required for malignant transformation.
UR - http://www.scopus.com/inward/record.url?scp=84961807876&partnerID=8YFLogxK
U2 - 10.1002/ACN3.184
DO - 10.1002/ACN3.184
M3 - Article
AN - SCOPUS:84961807876
SN - 2328-9503
VL - 2
SP - 439
EP - 443
JO - Annals of Clinical and Translational Neurology
JF - Annals of Clinical and Translational Neurology
IS - 4
ER -