Long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in a large pooled European cohort: ELAPSE study

Zorana J. Andersen; Jiawei Zhang; Jeanette T. Jørgensen; Evangelia Samoli; Shuo Liu; Jie Chen; Maciej Strak; Kathrin Wolf; Gudrun Weinmayr; Sophia Rodopolou; Elizabeth Remfry; Kees de Hoogh; Tom Bellander; Jørgen Brandt; Hans Concin; Emanuel Zitt; Daniela Fecht; Francesco Forastiere; John Gulliver; Barbara Hoffmann; Ulla A. Hvidtfeldt; W. M. Monique Verschuren; Karl Heinz Jöckel; Rina So; Tom Cole-Hunter; Amar J. Mehta; Laust H. Mortensen; Matthias Ketzel; Anton Lager; Karin Leander; Petter Ljungman; Gianluca Severi; Marie Christine Boutron-Ruault; Patrik K.E. Magnusson; Gabriele Nagel; Göran Pershagen; Annette Peters; Debora Rizzuto; Yvonne T. van der Schouw; Sara Schramm; Massimo Stafoggia; Klea Katsouyanni; Bert Brunekreef; Gerard Hoek; Youn Hee Lim

doi:10.1016/j.envint.2022.107581

Long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in a large pooled European cohort: ELAPSE study

Zorana J. Andersen, Jiawei Zhang, Jeanette T. Jørgensen, Evangelia Samoli, Shuo Liu, Jie Chen, Maciej Strak, Kathrin Wolf, Gudrun Weinmayr, Sophia Rodopolou, Elizabeth Remfry, Kees de Hoogh, Tom Bellander, Jørgen Brandt, Hans Concin, Emanuel Zitt, Daniela Fecht, Francesco Forastiere, John Gulliver, Barbara HoffmannUlla A. Hvidtfeldt, W. M. Monique Verschuren, Karl Heinz Jöckel, Rina So, Tom Cole-Hunter, Amar J. Mehta, Laust H. Mortensen, Matthias Ketzel, Anton Lager, Karin Leander, Petter Ljungman, Gianluca Severi, Marie Christine Boutron-Ruault, Patrik K.E. Magnusson, Gabriele Nagel, Göran Pershagen, Annette Peters, Debora Rizzuto, Yvonne T. van der Schouw, Sara Schramm, Massimo Stafoggia, Klea Katsouyanni, Bert Brunekreef, Gerard Hoek, Youn Hee Lim

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

16 Citations (Scopus)

Résumé

Ambient air pollution is an established risk factor for premature mortality from chronic cardiovascular, respiratory and metabolic diseases, while evidence on neurodegenerative diseases and psychiatric disorders remains limited. We examined the association between long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in seven European cohorts. Within the multicenter project ‘Effects of Low-Level Air Pollution: A Study in Europe’ (ELAPSE), we pooled data from seven European cohorts from six countries. Based on the residential addresses, annual mean levels of fine particulate matter (PM_2.5), nitrogen dioxide (NO₂), black carbon (BC), ozone (O₃), and 8 PM_2.5 components were estimated using Europe-wide hybrid land-use regression models. We applied stratified Cox proportional hazard models to investigate the associations between air pollution and mortality from dementia, psychiatric disorders, and suicide. Of 271,720 participants, 900 died from dementia, 241 from psychiatric disorders, and 164 from suicide, during a mean follow-up of 19.7 years. In fully adjusted models, we observed positive associations of NO₂ (hazard ratio [HR] = 1.38; 95 % confidence interval [CI]: 1.13, 1.70 per 10 µg/m³), PM_2.5 (HR = 1.29; 95 % CI: 0.98, 1.71 per 5 µg/m³), and BC (HR = 1.37; 95 % CI: 1.11, 1.69 per 0.5 × 10⁻⁵/m) with psychiatric disorders mortality, as well as with suicide (NO₂: HR = 1.13 [95 % CI: 0.92, 1.38]; PM_2.5: HR = 1.19 [95 % CI: 0.76, 1.87]; BC: HR = 1.08 [95 % CI: 0.87, 1.35]), and no association with dementia mortality. We did not detect any positive associations of O₃ and 8 PM_2.5 components with any of the three mortality outcomes. Long-term exposure to NO₂, PM_2.5, and BC may lead to premature mortality from psychiatric disorders and suicide.

langue originale	Anglais
Numéro d'article	107581
journal	Environment International
Volume	170
Les DOIs	https://doi.org/10.1016/j.envint.2022.107581
état	Publié - 1 déc. 2022
Modification externe	Oui

Accès au document

10.1016/j.envint.2022.107581

Autres fichiers et liens

Lien vers la publication dans Scopus

Contient cette citation

Andersen, Z. J., Zhang, J., Jørgensen, J. T., Samoli, E., Liu, S., Chen, J., Strak, M., Wolf, K., Weinmayr, G., Rodopolou, S., Remfry, E., de Hoogh, K., Bellander, T., Brandt, J., Concin, H., Zitt, E., Fecht, D., Forastiere, F., Gulliver, J., ... Lim, Y. H. (2022). Long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in a large pooled European cohort: ELAPSE study. Environment International, 170, Article 107581. https://doi.org/10.1016/j.envint.2022.107581

@article{f3bb525932d84419864865e2e9cc2f24,

title = "Long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in a large pooled European cohort: ELAPSE study",

abstract = "Ambient air pollution is an established risk factor for premature mortality from chronic cardiovascular, respiratory and metabolic diseases, while evidence on neurodegenerative diseases and psychiatric disorders remains limited. We examined the association between long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in seven European cohorts. Within the multicenter project {\textquoteleft}Effects of Low-Level Air Pollution: A Study in Europe{\textquoteright} (ELAPSE), we pooled data from seven European cohorts from six countries. Based on the residential addresses, annual mean levels of fine particulate matter (PM2.5), nitrogen dioxide (NO2), black carbon (BC), ozone (O3), and 8 PM2.5 components were estimated using Europe-wide hybrid land-use regression models. We applied stratified Cox proportional hazard models to investigate the associations between air pollution and mortality from dementia, psychiatric disorders, and suicide. Of 271,720 participants, 900 died from dementia, 241 from psychiatric disorders, and 164 from suicide, during a mean follow-up of 19.7 years. In fully adjusted models, we observed positive associations of NO2 (hazard ratio [HR] = 1.38; 95 % confidence interval [CI]: 1.13, 1.70 per 10 µg/m3), PM2.5 (HR = 1.29; 95 % CI: 0.98, 1.71 per 5 µg/m3), and BC (HR = 1.37; 95 % CI: 1.11, 1.69 per 0.5 × 10−5/m) with psychiatric disorders mortality, as well as with suicide (NO2: HR = 1.13 [95 % CI: 0.92, 1.38]; PM2.5: HR = 1.19 [95 % CI: 0.76, 1.87]; BC: HR = 1.08 [95 % CI: 0.87, 1.35]), and no association with dementia mortality. We did not detect any positive associations of O3 and 8 PM2.5 components with any of the three mortality outcomes. Long-term exposure to NO2, PM2.5, and BC may lead to premature mortality from psychiatric disorders and suicide.",

keywords = "Air pollution, Dementia, Long-term exposure, Mortality, Psychiatric disorders, Suicide",

author = "Andersen, {Zorana J.} and Jiawei Zhang and J{\o}rgensen, {Jeanette T.} and Evangelia Samoli and Shuo Liu and Jie Chen and Maciej Strak and Kathrin Wolf and Gudrun Weinmayr and Sophia Rodopolou and Elizabeth Remfry and {de Hoogh}, Kees and Tom Bellander and J{\o}rgen Brandt and Hans Concin and Emanuel Zitt and Daniela Fecht and Francesco Forastiere and John Gulliver and Barbara Hoffmann and Hvidtfeldt, {Ulla A.} and {Monique Verschuren}, {W. M.} and J{\"o}ckel, {Karl Heinz} and Rina So and Tom Cole-Hunter and Mehta, {Amar J.} and Mortensen, {Laust H.} and Matthias Ketzel and Anton Lager and Karin Leander and Petter Ljungman and Gianluca Severi and Boutron-Ruault, {Marie Christine} and Magnusson, {Patrik K.E.} and Gabriele Nagel and G{\"o}ran Pershagen and Annette Peters and Debora Rizzuto and {van der Schouw}, {Yvonne T.} and Sara Schramm and Massimo Stafoggia and Klea Katsouyanni and Bert Brunekreef and Gerard Hoek and Lim, {Youn Hee}",

note = "Publisher Copyright: {\textcopyright} 2022",

year = "2022",

month = dec,

day = "1",

doi = "10.1016/j.envint.2022.107581",

language = "English",

volume = "170",

journal = "Environment International",

issn = "0160-4120",

}

Andersen, ZJ, Zhang, J, Jørgensen, JT, Samoli, E, Liu, S, Chen, J, Strak, M, Wolf, K, Weinmayr, G, Rodopolou, S, Remfry, E, de Hoogh, K, Bellander, T, Brandt, J, Concin, H, Zitt, E, Fecht, D, Forastiere, F, Gulliver, J, Hoffmann, B, Hvidtfeldt, UA, Monique Verschuren, WM, Jöckel, KH, So, R, Cole-Hunter, T, Mehta, AJ, Mortensen, LH, Ketzel, M, Lager, A, Leander, K, Ljungman, P, Severi, G, Boutron-Ruault, MC, Magnusson, PKE, Nagel, G, Pershagen, G, Peters, A, Rizzuto, D, van der Schouw, YT, Schramm, S, Stafoggia, M, Katsouyanni, K, Brunekreef, B, Hoek, G & Lim, YH 2022, 'Long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in a large pooled European cohort: ELAPSE study', Environment International, VOL. 170, 107581. https://doi.org/10.1016/j.envint.2022.107581

TY - JOUR

T1 - Long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in a large pooled European cohort

T2 - ELAPSE study

AU - Andersen, Zorana J.

AU - Zhang, Jiawei

AU - Jørgensen, Jeanette T.

AU - Samoli, Evangelia

AU - Liu, Shuo

AU - Chen, Jie

AU - Strak, Maciej

AU - Wolf, Kathrin

AU - Weinmayr, Gudrun

AU - Rodopolou, Sophia

AU - Remfry, Elizabeth

AU - de Hoogh, Kees

AU - Bellander, Tom

AU - Brandt, Jørgen

AU - Concin, Hans

AU - Zitt, Emanuel

AU - Fecht, Daniela

AU - Forastiere, Francesco

AU - Gulliver, John

AU - Hoffmann, Barbara

AU - Hvidtfeldt, Ulla A.

AU - Monique Verschuren, W. M.

AU - Jöckel, Karl Heinz

AU - So, Rina

AU - Cole-Hunter, Tom

AU - Mehta, Amar J.

AU - Mortensen, Laust H.

AU - Ketzel, Matthias

AU - Lager, Anton

AU - Leander, Karin

AU - Ljungman, Petter

AU - Severi, Gianluca

AU - Boutron-Ruault, Marie Christine

AU - Magnusson, Patrik K.E.

AU - Nagel, Gabriele

AU - Pershagen, Göran

AU - Peters, Annette

AU - Rizzuto, Debora

AU - van der Schouw, Yvonne T.

AU - Schramm, Sara

AU - Stafoggia, Massimo

AU - Katsouyanni, Klea

AU - Brunekreef, Bert

AU - Hoek, Gerard

AU - Lim, Youn Hee

PY - 2022/12/1

Y1 - 2022/12/1

N2 - Ambient air pollution is an established risk factor for premature mortality from chronic cardiovascular, respiratory and metabolic diseases, while evidence on neurodegenerative diseases and psychiatric disorders remains limited. We examined the association between long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in seven European cohorts. Within the multicenter project ‘Effects of Low-Level Air Pollution: A Study in Europe’ (ELAPSE), we pooled data from seven European cohorts from six countries. Based on the residential addresses, annual mean levels of fine particulate matter (PM2.5), nitrogen dioxide (NO2), black carbon (BC), ozone (O3), and 8 PM2.5 components were estimated using Europe-wide hybrid land-use regression models. We applied stratified Cox proportional hazard models to investigate the associations between air pollution and mortality from dementia, psychiatric disorders, and suicide. Of 271,720 participants, 900 died from dementia, 241 from psychiatric disorders, and 164 from suicide, during a mean follow-up of 19.7 years. In fully adjusted models, we observed positive associations of NO2 (hazard ratio [HR] = 1.38; 95 % confidence interval [CI]: 1.13, 1.70 per 10 µg/m3), PM2.5 (HR = 1.29; 95 % CI: 0.98, 1.71 per 5 µg/m3), and BC (HR = 1.37; 95 % CI: 1.11, 1.69 per 0.5 × 10−5/m) with psychiatric disorders mortality, as well as with suicide (NO2: HR = 1.13 [95 % CI: 0.92, 1.38]; PM2.5: HR = 1.19 [95 % CI: 0.76, 1.87]; BC: HR = 1.08 [95 % CI: 0.87, 1.35]), and no association with dementia mortality. We did not detect any positive associations of O3 and 8 PM2.5 components with any of the three mortality outcomes. Long-term exposure to NO2, PM2.5, and BC may lead to premature mortality from psychiatric disorders and suicide.

AB - Ambient air pollution is an established risk factor for premature mortality from chronic cardiovascular, respiratory and metabolic diseases, while evidence on neurodegenerative diseases and psychiatric disorders remains limited. We examined the association between long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in seven European cohorts. Within the multicenter project ‘Effects of Low-Level Air Pollution: A Study in Europe’ (ELAPSE), we pooled data from seven European cohorts from six countries. Based on the residential addresses, annual mean levels of fine particulate matter (PM2.5), nitrogen dioxide (NO2), black carbon (BC), ozone (O3), and 8 PM2.5 components were estimated using Europe-wide hybrid land-use regression models. We applied stratified Cox proportional hazard models to investigate the associations between air pollution and mortality from dementia, psychiatric disorders, and suicide. Of 271,720 participants, 900 died from dementia, 241 from psychiatric disorders, and 164 from suicide, during a mean follow-up of 19.7 years. In fully adjusted models, we observed positive associations of NO2 (hazard ratio [HR] = 1.38; 95 % confidence interval [CI]: 1.13, 1.70 per 10 µg/m3), PM2.5 (HR = 1.29; 95 % CI: 0.98, 1.71 per 5 µg/m3), and BC (HR = 1.37; 95 % CI: 1.11, 1.69 per 0.5 × 10−5/m) with psychiatric disorders mortality, as well as with suicide (NO2: HR = 1.13 [95 % CI: 0.92, 1.38]; PM2.5: HR = 1.19 [95 % CI: 0.76, 1.87]; BC: HR = 1.08 [95 % CI: 0.87, 1.35]), and no association with dementia mortality. We did not detect any positive associations of O3 and 8 PM2.5 components with any of the three mortality outcomes. Long-term exposure to NO2, PM2.5, and BC may lead to premature mortality from psychiatric disorders and suicide.

KW - Air pollution

KW - Dementia

KW - Long-term exposure

KW - Mortality

KW - Psychiatric disorders

KW - Suicide

UR - http://www.scopus.com/inward/record.url?scp=85139849287&partnerID=8YFLogxK

U2 - 10.1016/j.envint.2022.107581

DO - 10.1016/j.envint.2022.107581

M3 - Article

C2 - 36244228

AN - SCOPUS:85139849287

SN - 0160-4120

VL - 170

JO - Environment International

JF - Environment International

M1 - 107581

ER -