Long-Term Exposure to Source-Specific Fine Particles and Mortality-A Pooled Analysis of 14 European Cohorts within the ELAPSE Project

Jie Chen; Gerard Hoek; Kees De Hoogh; Sophia Rodopoulou; Zorana J. Andersen; Tom Bellander; Jørgen Brandt; Daniela Fecht; Francesco Forastiere; John Gulliver; Ole Hertel; Barbara Hoffmann; Ulla Arthur Hvidtfeldt; W. M.Monique Verschuren; Karl Heinz Jöckel; Jeanette T. Jørgensen; Klea Katsouyanni; Matthias Ketzel; Diego Yacamán Méndez; Karin Leander; Shuo Liu; Petter Ljungman; Elodie Faure; Patrik K.E. Magnusson; Gabriele Nagel; Göran Pershagen; Annette Peters; Ole Raaschou-Nielsen; Debora Rizzuto; Evangelia Samoli; Yvonne T. Van Der Schouw; Sara Schramm; Gianluca Severi; Massimo Stafoggia; Maciej Strak; Mette Sørensen; Anne Tjønneland; Gudrun Weinmayr; Kathrin Wolf; Emanuel Zitt; Bert Brunekreef; George D. Thurston

doi:10.1021/acs.est.2c01912

Long-Term Exposure to Source-Specific Fine Particles and Mortality-A Pooled Analysis of 14 European Cohorts within the ELAPSE Project

Jie Chen, Gerard Hoek, Kees De Hoogh, Sophia Rodopoulou, Zorana J. Andersen, Tom Bellander, Jørgen Brandt, Daniela Fecht, Francesco Forastiere, John Gulliver, Ole Hertel, Barbara Hoffmann, Ulla Arthur Hvidtfeldt, W. M.Monique Verschuren, Karl Heinz Jöckel, Jeanette T. Jørgensen, Klea Katsouyanni, Matthias Ketzel, Diego Yacamán Méndez, Karin LeanderShuo Liu, Petter Ljungman, Elodie Faure, Patrik K.E. Magnusson, Gabriele Nagel, Göran Pershagen, Annette Peters, Ole Raaschou-Nielsen, Debora Rizzuto, Evangelia Samoli, Yvonne T. Van Der Schouw, Sara Schramm, Gianluca Severi, Massimo Stafoggia, Maciej Strak, Mette Sørensen, Anne Tjønneland, Gudrun Weinmayr, Kathrin Wolf, Emanuel Zitt, Bert Brunekreef, George D. Thurston

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

16 Citations (Scopus)

Résumé

We assessed mortality risks associated with source-specific fine particles (PM_2.5) in a pooled European cohort of 323,782 participants. Cox proportional hazard models were applied to estimate mortality hazard ratios (HRs) for source-specific PM_2.5identified through a source apportionment analysis. Exposure to 2010 annual average concentrations of source-specific PM_2.5components was assessed at baseline residential addresses. The source apportionment resulted in the identification of five sources: traffic, residual oil combustion, soil, biomass and agriculture, and industry. In single-source analysis, all identified sources were significantly positively associated with increased natural mortality risks. In multisource analysis, associations with all sources attenuated but remained statistically significant with traffic, oil, and biomass and agriculture. The highest association per interquartile increase was observed for the traffic component (HR: 1.06; 95% CI: 1.04 and 1.08 per 2.86 μg/m³increase) across five identified sources. On a 1 μg/m³basis, the residual oil-related PM_2.5had the strongest association (HR: 1.13; 95% CI: 1.05 and 1.22), which was substantially higher than that for generic PM_2.5mass, suggesting that past estimates using the generic PM_2.5exposure response function have underestimated the potential clean air health benefits of reducing fossil-fuel combustion. Source-specific associations with cause-specific mortality were in general consistent with findings of natural mortality.

langue originale	Anglais
Pages (de - à)	9277-9290
Nombre de pages	14
journal	Environmental Science and Technology
Volume	56
Numéro de publication	13
Les DOIs	https://doi.org/10.1021/acs.est.2c01912
état	Publié - 5 juil. 2022
Modification externe	Oui

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10.1021/acs.est.2c01912

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Chen, J., Hoek, G., De Hoogh, K., Rodopoulou, S., Andersen, Z. J., Bellander, T., Brandt, J., Fecht, D., Forastiere, F., Gulliver, J., Hertel, O., Hoffmann, B., Hvidtfeldt, U. A., Verschuren, W. M. M., Jöckel, K. H., Jørgensen, J. T., Katsouyanni, K., Ketzel, M., Méndez, D. Y., ... Thurston, G. D. (2022). Long-Term Exposure to Source-Specific Fine Particles and Mortality-A Pooled Analysis of 14 European Cohorts within the ELAPSE Project. Environmental Science and Technology, 56(13), 9277-9290. https://doi.org/10.1021/acs.est.2c01912

@article{edcaeab5c641450eb6637da27610cff9,

title = "Long-Term Exposure to Source-Specific Fine Particles and Mortality-A Pooled Analysis of 14 European Cohorts within the ELAPSE Project",

abstract = "We assessed mortality risks associated with source-specific fine particles (PM2.5) in a pooled European cohort of 323,782 participants. Cox proportional hazard models were applied to estimate mortality hazard ratios (HRs) for source-specific PM2.5identified through a source apportionment analysis. Exposure to 2010 annual average concentrations of source-specific PM2.5components was assessed at baseline residential addresses. The source apportionment resulted in the identification of five sources: traffic, residual oil combustion, soil, biomass and agriculture, and industry. In single-source analysis, all identified sources were significantly positively associated with increased natural mortality risks. In multisource analysis, associations with all sources attenuated but remained statistically significant with traffic, oil, and biomass and agriculture. The highest association per interquartile increase was observed for the traffic component (HR: 1.06; 95% CI: 1.04 and 1.08 per 2.86 μg/m3increase) across five identified sources. On a 1 μg/m3basis, the residual oil-related PM2.5had the strongest association (HR: 1.13; 95% CI: 1.05 and 1.22), which was substantially higher than that for generic PM2.5mass, suggesting that past estimates using the generic PM2.5exposure response function have underestimated the potential clean air health benefits of reducing fossil-fuel combustion. Source-specific associations with cause-specific mortality were in general consistent with findings of natural mortality.",

keywords = "absolute principal component analysis (APCA), fine particulate matter (PM), mortality, source apportionment",

author = "Jie Chen and Gerard Hoek and {De Hoogh}, Kees and Sophia Rodopoulou and Andersen, {Zorana J.} and Tom Bellander and J{\o}rgen Brandt and Daniela Fecht and Francesco Forastiere and John Gulliver and Ole Hertel and Barbara Hoffmann and Hvidtfeldt, {Ulla Arthur} and Verschuren, {W. M.Monique} and J{\"o}ckel, {Karl Heinz} and J{\o}rgensen, {Jeanette T.} and Klea Katsouyanni and Matthias Ketzel and M{\'e}ndez, {Diego Yacam{\'a}n} and Karin Leander and Shuo Liu and Petter Ljungman and Elodie Faure and Magnusson, {Patrik K.E.} and Gabriele Nagel and G{\"o}ran Pershagen and Annette Peters and Ole Raaschou-Nielsen and Debora Rizzuto and Evangelia Samoli and {Van Der Schouw}, {Yvonne T.} and Sara Schramm and Gianluca Severi and Massimo Stafoggia and Maciej Strak and Mette S{\o}rensen and Anne Tj{\o}nneland and Gudrun Weinmayr and Kathrin Wolf and Emanuel Zitt and Bert Brunekreef and Thurston, {George D.}",

year = "2022",

month = jul,

day = "5",

doi = "10.1021/acs.est.2c01912",

language = "English",

volume = "56",

pages = "9277--9290",

journal = "Environmental Science and Technology",

issn = "0013-936X",

number = "13",

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Chen, J, Hoek, G, De Hoogh, K, Rodopoulou, S, Andersen, ZJ, Bellander, T, Brandt, J, Fecht, D, Forastiere, F, Gulliver, J, Hertel, O, Hoffmann, B, Hvidtfeldt, UA, Verschuren, WMM, Jöckel, KH, Jørgensen, JT, Katsouyanni, K, Ketzel, M, Méndez, DY, Leander, K, Liu, S, Ljungman, P, Faure, E, Magnusson, PKE, Nagel, G, Pershagen, G, Peters, A, Raaschou-Nielsen, O, Rizzuto, D, Samoli, E, Van Der Schouw, YT, Schramm, S, Severi, G, Stafoggia, M, Strak, M, Sørensen, M, Tjønneland, A, Weinmayr, G, Wolf, K, Zitt, E, Brunekreef, B & Thurston, GD 2022, 'Long-Term Exposure to Source-Specific Fine Particles and Mortality-A Pooled Analysis of 14 European Cohorts within the ELAPSE Project', Environmental Science and Technology, VOL. 56, Numéro 13, p. 9277-9290. https://doi.org/10.1021/acs.est.2c01912

TY - JOUR

T1 - Long-Term Exposure to Source-Specific Fine Particles and Mortality-A Pooled Analysis of 14 European Cohorts within the ELAPSE Project

AU - Chen, Jie

AU - Hoek, Gerard

AU - De Hoogh, Kees

AU - Rodopoulou, Sophia

AU - Andersen, Zorana J.

AU - Bellander, Tom

AU - Brandt, Jørgen

AU - Fecht, Daniela

AU - Forastiere, Francesco

AU - Gulliver, John

AU - Hertel, Ole

AU - Hoffmann, Barbara

AU - Hvidtfeldt, Ulla Arthur

AU - Verschuren, W. M.Monique

AU - Jöckel, Karl Heinz

AU - Jørgensen, Jeanette T.

AU - Katsouyanni, Klea

AU - Ketzel, Matthias

AU - Méndez, Diego Yacamán

AU - Leander, Karin

AU - Liu, Shuo

AU - Ljungman, Petter

AU - Faure, Elodie

AU - Magnusson, Patrik K.E.

AU - Nagel, Gabriele

AU - Pershagen, Göran

AU - Peters, Annette

AU - Raaschou-Nielsen, Ole

AU - Rizzuto, Debora

AU - Samoli, Evangelia

AU - Van Der Schouw, Yvonne T.

AU - Schramm, Sara

AU - Severi, Gianluca

AU - Stafoggia, Massimo

AU - Strak, Maciej

AU - Sørensen, Mette

AU - Tjønneland, Anne

AU - Weinmayr, Gudrun

AU - Wolf, Kathrin

AU - Zitt, Emanuel

AU - Brunekreef, Bert

AU - Thurston, George D.

PY - 2022/7/5

Y1 - 2022/7/5

N2 - We assessed mortality risks associated with source-specific fine particles (PM2.5) in a pooled European cohort of 323,782 participants. Cox proportional hazard models were applied to estimate mortality hazard ratios (HRs) for source-specific PM2.5identified through a source apportionment analysis. Exposure to 2010 annual average concentrations of source-specific PM2.5components was assessed at baseline residential addresses. The source apportionment resulted in the identification of five sources: traffic, residual oil combustion, soil, biomass and agriculture, and industry. In single-source analysis, all identified sources were significantly positively associated with increased natural mortality risks. In multisource analysis, associations with all sources attenuated but remained statistically significant with traffic, oil, and biomass and agriculture. The highest association per interquartile increase was observed for the traffic component (HR: 1.06; 95% CI: 1.04 and 1.08 per 2.86 μg/m3increase) across five identified sources. On a 1 μg/m3basis, the residual oil-related PM2.5had the strongest association (HR: 1.13; 95% CI: 1.05 and 1.22), which was substantially higher than that for generic PM2.5mass, suggesting that past estimates using the generic PM2.5exposure response function have underestimated the potential clean air health benefits of reducing fossil-fuel combustion. Source-specific associations with cause-specific mortality were in general consistent with findings of natural mortality.

AB - We assessed mortality risks associated with source-specific fine particles (PM2.5) in a pooled European cohort of 323,782 participants. Cox proportional hazard models were applied to estimate mortality hazard ratios (HRs) for source-specific PM2.5identified through a source apportionment analysis. Exposure to 2010 annual average concentrations of source-specific PM2.5components was assessed at baseline residential addresses. The source apportionment resulted in the identification of five sources: traffic, residual oil combustion, soil, biomass and agriculture, and industry. In single-source analysis, all identified sources were significantly positively associated with increased natural mortality risks. In multisource analysis, associations with all sources attenuated but remained statistically significant with traffic, oil, and biomass and agriculture. The highest association per interquartile increase was observed for the traffic component (HR: 1.06; 95% CI: 1.04 and 1.08 per 2.86 μg/m3increase) across five identified sources. On a 1 μg/m3basis, the residual oil-related PM2.5had the strongest association (HR: 1.13; 95% CI: 1.05 and 1.22), which was substantially higher than that for generic PM2.5mass, suggesting that past estimates using the generic PM2.5exposure response function have underestimated the potential clean air health benefits of reducing fossil-fuel combustion. Source-specific associations with cause-specific mortality were in general consistent with findings of natural mortality.

KW - absolute principal component analysis (APCA)

KW - fine particulate matter (PM)

KW - mortality

KW - source apportionment

UR - http://www.scopus.com/inward/record.url?scp=85134084148&partnerID=8YFLogxK

U2 - 10.1021/acs.est.2c01912

DO - 10.1021/acs.est.2c01912

M3 - Article

C2 - 35737879

AN - SCOPUS:85134084148

SN - 0013-936X

VL - 56

SP - 9277

EP - 9290

JO - Environmental Science and Technology

JF - Environmental Science and Technology

IS - 13

ER -