Loss of the TEL/ETV6 gene by a second translocation in ALL patients with t(12;21)

Maryvonne Busson-Le Coniat; H. Élène Poirel; Thierry Leblanc; Olivier A. Bernard; Roland Berger

doi:10.1016/S0145-2126(99)00105-8

Loss of the TEL/ETV6 gene by a second translocation in ALL patients with t(12;21)

Maryvonne Busson-Le Coniat, H. Élène Poirel, Thierry Leblanc, Olivier A. Bernard, Roland Berger

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Résumé

Inactivation of the non translocated TEL/ETV6 gene is commonly associated with translocation (12;21) of acute lymphoblastic leukemia (ALL). Translocations involving the short arm of chromosome 12 were analysed in two children with t(12;21) ALL. Fluorescence in situ hybridation studies showed that these associated translocations resulted in loss of TEL/ETV6. While hybridization with a YAC probe covering TEL/ETV6 was positive in one patient, analysis with cosmid probes covering the gene demonstrated that the gene was in fact deleted. It is concluded that deletions involving TEL/ETV6 can remain undetected by FISH using only YAC probes.

langue originale	Anglais
Pages (de - à)	895-899
Nombre de pages	5
journal	Leukemia Research
Volume	23
Numéro de publication	10
Les DOIs	https://doi.org/10.1016/S0145-2126(99)00105-8
état	Publié - 1 oct. 1999
Modification externe	Oui

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10.1016/S0145-2126(99)00105-8

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@article{7ac4474eaa6b45288513901f470c27f3,

title = "Loss of the TEL/ETV6 gene by a second translocation in ALL patients with t(12;21)",

abstract = "Inactivation of the non translocated TEL/ETV6 gene is commonly associated with translocation (12;21) of acute lymphoblastic leukemia (ALL). Translocations involving the short arm of chromosome 12 were analysed in two children with t(12;21) ALL. Fluorescence in situ hybridation studies showed that these associated translocations resulted in loss of TEL/ETV6. While hybridization with a YAC probe covering TEL/ETV6 was positive in one patient, analysis with cosmid probes covering the gene demonstrated that the gene was in fact deleted. It is concluded that deletions involving TEL/ETV6 can remain undetected by FISH using only YAC probes.",

keywords = "Acute lymphoblastic leukemia, ETV6, Gene loss, TEL, Translocation, t(12;21)",

author = "{Busson-Le Coniat}, Maryvonne and Poirel, {H. {\'E}l{\`e}ne} and Thierry Leblanc and Bernard, {Olivier A.} and Roland Berger",

note = "Funding Information: This work was partly supported by the Ligue Nationale contre le Cancer, l{\textquoteright}ARC. M. Busson Le-Coniat provided the design of the study. H. Poriel and O. Bernard provided critical revision for important intellectual content of the article. T. Leblanc provided study materials. R. Berger drafted the article, provided analysis and data interpretation and gave final approval.",

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T1 - Loss of the TEL/ETV6 gene by a second translocation in ALL patients with t(12;21)

AU - Busson-Le Coniat, Maryvonne

AU - Poirel, H. Élène

AU - Leblanc, Thierry

AU - Bernard, Olivier A.

AU - Berger, Roland

N1 - Funding Information: This work was partly supported by the Ligue Nationale contre le Cancer, l’ARC. M. Busson Le-Coniat provided the design of the study. H. Poriel and O. Bernard provided critical revision for important intellectual content of the article. T. Leblanc provided study materials. R. Berger drafted the article, provided analysis and data interpretation and gave final approval.

PY - 1999/10/1

Y1 - 1999/10/1

N2 - Inactivation of the non translocated TEL/ETV6 gene is commonly associated with translocation (12;21) of acute lymphoblastic leukemia (ALL). Translocations involving the short arm of chromosome 12 were analysed in two children with t(12;21) ALL. Fluorescence in situ hybridation studies showed that these associated translocations resulted in loss of TEL/ETV6. While hybridization with a YAC probe covering TEL/ETV6 was positive in one patient, analysis with cosmid probes covering the gene demonstrated that the gene was in fact deleted. It is concluded that deletions involving TEL/ETV6 can remain undetected by FISH using only YAC probes.

AB - Inactivation of the non translocated TEL/ETV6 gene is commonly associated with translocation (12;21) of acute lymphoblastic leukemia (ALL). Translocations involving the short arm of chromosome 12 were analysed in two children with t(12;21) ALL. Fluorescence in situ hybridation studies showed that these associated translocations resulted in loss of TEL/ETV6. While hybridization with a YAC probe covering TEL/ETV6 was positive in one patient, analysis with cosmid probes covering the gene demonstrated that the gene was in fact deleted. It is concluded that deletions involving TEL/ETV6 can remain undetected by FISH using only YAC probes.

KW - Acute lymphoblastic leukemia

KW - ETV6

KW - Gene loss

KW - TEL

KW - Translocation

KW - t(12;21)

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