Low central nervous system posaconazole concentrations during cerebral phaeohyphomycosis

François Barde; Eliane Billaud; Lauriane Goldwirt; Catherine Horodyckid; Vincent Jullien; Fanny Lanternier; Philippe Lesprit; Lucie Limousin; Jérémie F. Cohen; Olivier Lortholary

doi:10.1128/AAC.01184-19

Low central nervous system posaconazole concentrations during cerebral phaeohyphomycosis

François Barde, Eliane Billaud, Lauriane Goldwirt, Catherine Horodyckid, Vincent Jullien, Fanny Lanternier, Philippe Lesprit, Lucie Limousin, Jérémie F. Cohen, Olivier Lortholary

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

19 Citations (Scopus)

Résumé

Posaconazole diffusion has been documented in various organs, which contrasts with the scarce data available for the human central nervous system (CNS). We analyzed posaconazole concentrations in plasma and multiple CNS specimens taken from a patient who received posaconazole because of cerebral phaeohyphomycosis. Low posaconazole concentrations were obtained in CNS specimens, with sample-to-plasma ratios between 5% and 22%. This case highlights the role of neurosurgery during cerebral phaeohyphomycoses, even those caused by posaconazole-susceptible black fungi.

langue originale	Anglais
Numéro d'article	e01184-19
journal	Antimicrobial Agents and Chemotherapy
Volume	63
Numéro de publication	11
Les DOIs	https://doi.org/10.1128/AAC.01184-19
état	Publié - 1 janv. 2019
Modification externe	Oui

Accès au document

10.1128/AAC.01184-19

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title = "Low central nervous system posaconazole concentrations during cerebral phaeohyphomycosis",

abstract = "Posaconazole diffusion has been documented in various organs, which contrasts with the scarce data available for the human central nervous system (CNS). We analyzed posaconazole concentrations in plasma and multiple CNS specimens taken from a patient who received posaconazole because of cerebral phaeohyphomycosis. Low posaconazole concentrations were obtained in CNS specimens, with sample-to-plasma ratios between 5% and 22%. This case highlights the role of neurosurgery during cerebral phaeohyphomycoses, even those caused by posaconazole-susceptible black fungi.",

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AU - Barde, François

AU - Billaud, Eliane

AU - Goldwirt, Lauriane

AU - Horodyckid, Catherine

AU - Jullien, Vincent

AU - Lanternier, Fanny

AU - Lesprit, Philippe

AU - Limousin, Lucie

AU - Cohen, Jérémie F.

AU - Lortholary, Olivier

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