Management of brain metastases in lung carcinoma

Brain metastases are common in the natural history of lung cancer and are correlated with poor prognosis. Over the past ten years, the treatment of brain metastases has evolved considerably; a better understanding of the evolution and molecular biology of these processes has enabled the development of new treatments specifically targeting the Epidermal Growth Factor Receptor (EGFR) and the Anaplastic Lymphoma Kinase (ALK). Meanwhile, advances in imaging techniques have enabled early diagnosis of these tumors and improved assessment of the tumoral response. The repeated use of radiosurgery (SRS) or hippocampal-avoidance whole brain radiotherapy have allowed high tumor control rates and reduced radiation-induced cerebral injury. We summarized the treatment options and perspectives in the management of cerebral secondary lesions of lung cancer.