TY - JOUR
T1 - Manipulating the gut and tumor microbiota for immune checkpoint inhibitor therapy
T2 - from dream to reality
AU - Guillot, Nicolas
AU - Roméo, Barnabé
AU - Manesh, Shima Sepehri
AU - Milano, Gerard
AU - Brest, Patrick
AU - Zitvogel, Laurence
AU - Hofman, Paul
AU - Mograbi, Baharia
N1 - Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/11/1
Y1 - 2023/11/1
N2 - The past decade has witnessed a revolution in cancer treatment by shifting from conventional therapies to immune checkpoint inhibitors (ICIs). These immunotherapies unleash the host immune system against the tumor and have achieved unprecedented durable remission. However, 80% of patients do not respond. This review discusses how bacteria are unexpected drivers that reprogram tumor immunity. Manipulating the microbiota impacts on tumor development and reprograms the tumor microenvironment (TME) of mice on immunotherapy. We anticipate that harnessing commensals and the tumor microbiome holds promise to identify patients who will benefit from immunotherapy and guide the choice of new ICI combinations to advance treatment efficacy.
AB - The past decade has witnessed a revolution in cancer treatment by shifting from conventional therapies to immune checkpoint inhibitors (ICIs). These immunotherapies unleash the host immune system against the tumor and have achieved unprecedented durable remission. However, 80% of patients do not respond. This review discusses how bacteria are unexpected drivers that reprogram tumor immunity. Manipulating the microbiota impacts on tumor development and reprograms the tumor microenvironment (TME) of mice on immunotherapy. We anticipate that harnessing commensals and the tumor microbiome holds promise to identify patients who will benefit from immunotherapy and guide the choice of new ICI combinations to advance treatment efficacy.
KW - antibiotics
KW - commensal
KW - fecal microbiota transplantation
KW - immune checkpoint inhibitor therapy
KW - predictive biomarker
KW - probiotics
KW - tumor microbiota
UR - http://www.scopus.com/inward/record.url?scp=85170571409&partnerID=8YFLogxK
U2 - 10.1016/j.molmed.2023.08.004
DO - 10.1016/j.molmed.2023.08.004
M3 - Review article
AN - SCOPUS:85170571409
SN - 1471-4914
VL - 29
SP - 897
EP - 911
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 11
ER -