Manipulating the gut and tumor microbiota for immune checkpoint inhibitor therapy: from dream to reality

Nicolas Guillot, Barnabé Roméo, Shima Sepehri Manesh, Gerard Milano, Patrick Brest, Laurence Zitvogel, Paul Hofman, Baharia Mograbi

    Résultats de recherche: Contribution à un journalArticle 'review'Revue par des pairs

    11 Citations (Scopus)

    Résumé

    The past decade has witnessed a revolution in cancer treatment by shifting from conventional therapies to immune checkpoint inhibitors (ICIs). These immunotherapies unleash the host immune system against the tumor and have achieved unprecedented durable remission. However, 80% of patients do not respond. This review discusses how bacteria are unexpected drivers that reprogram tumor immunity. Manipulating the microbiota impacts on tumor development and reprograms the tumor microenvironment (TME) of mice on immunotherapy. We anticipate that harnessing commensals and the tumor microbiome holds promise to identify patients who will benefit from immunotherapy and guide the choice of new ICI combinations to advance treatment efficacy.

    langue originaleAnglais
    Pages (de - à)897-911
    Nombre de pages15
    journalTrends in Molecular Medicine
    Volume29
    Numéro de publication11
    Les DOIs
    étatPublié - 1 nov. 2023

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