Mecanismele fundamentale ale metastazãriişirezistenei la polichimioterapie în cancerele pulmonare

Ciprian Tomuleasa, Gabriel Kacso, Olga Soritau, Sergiu Susman, Bobe Petrushev, Mihaela Aldea, Rareş Buiga, Alexandru Irimie

Résultats de recherche: Contribution à un journalArticle 'review'Revue par des pairs

3 Citations (Scopus)

Résumé

Lung cancer is the leading cause of cancer-related death in the European Union and the United States, accounting for about one third of all cancer deaths. Primary lung cancer may arise from the central (bronchial) or peripheral (bronchiolo-alveolar) compartment of the lung, but the origins of the different histological types of primary lung tumours are not well understood and described in medical literature. Current investigation in the field of cancer research have focused on the "cancer stem cell" hypothesis as stem cells are belived to be crucial players in the homeostasis of all adult tissues. Even if the role of stem cells in lung carcinogenesis is not clear yet, numerous studies indicate that lung cancer is not the result of a sudden transforming event, but of a multistep process of molecular changes of the primordial stem cell niche, leading to the development of noeplasia. In the current review, we present state-of-the-art research in the field of lung stem cell biology, with a special emphasis on lung cancer emergence, development, metastasis and multidrug resistance.

Titre traduit de la contributionThe fundamental mechanisms of metastatic spread and chemotherapy resistance in lung cancer
langue originaleRoumain
Pages (de - à)99-103
Nombre de pages5
journalPneumologia
Volume60
Numéro de publication2
étatPublié - 3 nov. 2011
Modification externeOui

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